Phenotypes associated with this allele

• Allele Symbol: Popdc2^tm1Tbd
• Allele Name: targeted mutation 1, Thomas Brand
• Allele ID: MGI:3773727
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Popdc2^tm1Tbd/Popdc2^tm1Tbd	B6.129S2(FVB)-Popdc2^tm1Tbd	MGI:3798068

Genotype
MGI:3798068

hm1

• Allelic Composition: Popdc2^tm1Tbd/Popdc2^tm1Tbd
• Genetic Background: B6.129S2(FVB)-Popdc2^tm1Tbd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal sinoatrial node morphology ( J:184566 )

• pacemaker cells in mice older than 3 months exhibit fewer extensions compared with wild-type cells

• the node in mice older than 3 months is more compact than in wild-type mice

sinus bradycardia ( J:184566 )

• stress-induced at 5.5 and 8 months

abnormal sinoatrial node conduction ( J:184566 )

• long pauses and intercurrent periods of normal sinus rhythm upon stress at 5.5 and 8 months

• stress-induced pauses increase with age

• however, no block is observed

abnormal response of heart to induced stress ( J:184566 )

• at 5.5 and 8 months, exercised mice exhibit sinus bradycardia and abnormal sinoatrial node conduction unlike wild-type mice

• in response to mental stress and catecholamines, mice show a blunted increase in heart rate compared with wild-type mice

growth/size/body

slow postnatal weight gain ( J:184566 )

homeostasis/metabolism

abnormal response of heart to induced stress ( J:184566 )

• at 5.5 and 8 months, exercised mice exhibit sinus bradycardia and abnormal sinoatrial node conduction unlike wild-type mice

• in response to mental stress and catecholamines, mice show a blunted increase in heart rate compared with wild-type mice

muscle

abnormal sinoatrial node morphology ( J:184566 )

• pacemaker cells in mice older than 3 months exhibit fewer extensions compared with wild-type cells

• the node in mice older than 3 months is more compact than in wild-type mice