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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tcra,Tcrb)HRVAll
transgene insertion HRV, James P Allison
MGI:3773740
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Tcra,Tcrb)HRVAll/0
Tg(TRAMP)8247Ng/0 		B6.Cg-Tg(TRAMP)8247Ng Tg(Tcra,Tcrb)HRVAll MGI:3845008
tg2
 		Tg(Tcra,Tcrb)HRVAll/0 B6.Cg-Tg(Tcra,Tcrb)HRVAll MGI:3845007


Genotype
MGI:3845008
cx1
Allelic
Composition		 Tg(Tcra,Tcrb)HRVAll/0
Tg(TRAMP)8247Ng/0
Genetic
Background		 B6.Cg-Tg(TRAMP)8247Ng Tg(Tcra,Tcrb)HRVAll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra,Tcrb)HRVAll mutation (1 available)
Tg(TRAMP)8247Ng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:131347 )
• similar to in mice expressing Tg(TRAMP)8247Ng, survival is reduced to 26 to 28 weeks unlike in wild-type mice

neoplasm
increased tumor incidence ( J:131347 )
• mice develop prostate and genitourinary tract masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice
increased prostate gland tumor incidence ( J:131347 )
• mice develop prostate masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice

reproductive system
increased prostate gland tumor incidence ( J:131347 )
• mice develop prostate masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice

endocrine/exocrine glands
increased prostate gland tumor incidence ( J:131347 )
• mice develop prostate masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice




Genotype
MGI:3845007
tg2
Allelic
Composition		 Tg(Tcra,Tcrb)HRVAll/0
Genetic
Background		 B6.Cg-Tg(Tcra,Tcrb)HRVAll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra,Tcrb)HRVAll mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell subpopulation ratio ( J:131347 )
• the CD4+ to CD8+ T cell ratio is slightly shifted towards increased CD8+ T cells

hematopoietic system
abnormal T cell subpopulation ratio ( J:131347 )
• the CD4+ to CD8+ T cell ratio is slightly shifted towards increased CD8+ T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory