About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tcra,Tcrb)HRVAll
transgene insertion HRV, James P Allison
MGI:3773740
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Tcra,Tcrb)HRVAll/0
Tg(TRAMP)8247Ng/0 		B6.Cg-Tg(TRAMP)8247Ng Tg(Tcra,Tcrb)HRVAll MGI:3845008
tg2
 		Tg(Tcra,Tcrb)HRVAll/0 B6.Cg-Tg(Tcra,Tcrb)HRVAll MGI:3845007


Genotype
MGI:3845008
cx1
Allelic
Composition		 Tg(Tcra,Tcrb)HRVAll/0
Tg(TRAMP)8247Ng/0
Genetic
Background		 B6.Cg-Tg(TRAMP)8247Ng Tg(Tcra,Tcrb)HRVAll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra,Tcrb)HRVAll mutation (1 available)
Tg(TRAMP)8247Ng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:131347 )
• similar to in mice expressing Tg(TRAMP)8247Ng, survival is reduced to 26 to 28 weeks unlike in wild-type mice

neoplasm
increased tumor incidence ( J:131347 )
• mice develop prostate and genitourinary tract masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice
increased prostate gland tumor incidence ( J:131347 )
• mice develop prostate masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice

reproductive system
increased prostate gland tumor incidence ( J:131347 )
• mice develop prostate masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice

endocrine/exocrine glands
increased prostate gland tumor incidence ( J:131347 )
• mice develop prostate masses unlike wild-type mice but at a 10% reduced occurrence compared to in Tg(TRAMP)8247Ng expressing mice




Genotype
MGI:3845007
tg2
Allelic
Composition		 Tg(Tcra,Tcrb)HRVAll/0
Genetic
Background		 B6.Cg-Tg(Tcra,Tcrb)HRVAll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra,Tcrb)HRVAll mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell subpopulation ratio ( J:131347 )
• the CD4+ to CD8+ T cell ratio is slightly shifted towards increased CD8+ T cells

hematopoietic system
abnormal T cell subpopulation ratio ( J:131347 )
• the CD4+ to CD8+ T cell ratio is slightly shifted towards increased CD8+ T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory