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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tcra,Tcrb)HRCAll
transgene insertion HRC, James P Allison
MGI:3773741
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra,Tcrb)HRCAll/0 		B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll MGI:3845009
tg2
 		Tg(Tcra,Tcrb)HRCAll/0 B6.Cg-Tg(Tcra,Tcrb)HRCAll MGI:3845010


Genotype
MGI:3845009
cx1
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra,Tcrb)HRCAll/0
Genetic
Background		 B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(Tcra,Tcrb)HRCAll mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:131347 )
• mature peripheral T cells are selected to the CD8+ lineage
• however, mice do not exhibit clonal deletion or co-receptor downregulation in the thymus or activation in the periphery
abnormal T cell subpopulation ratio ( J:131347 )
• mature peripheral T cells are selected to the CD8+ lineage

hematopoietic system
abnormal T cell differentiation ( J:131347 )
• mature peripheral T cells are selected to the CD8+ lineage
• however, mice do not exhibit clonal deletion or co-receptor downregulation in the thymus or activation in the periphery
abnormal T cell subpopulation ratio ( J:131347 )
• mature peripheral T cells are selected to the CD8+ lineage




Genotype
MGI:3845010
tg2
Allelic
Composition		 Tg(Tcra,Tcrb)HRCAll/0
Genetic
Background		 B6.Cg-Tg(Tcra,Tcrb)HRCAll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra,Tcrb)HRCAll mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell subpopulation ratio ( J:131347 )
• the CD4+ to CD8+ T cell ratio is shifted towards increased CD8+ T cells
decreased cytotoxic T cell cytolysis ( J:131347 )
• despite proliferation and trafficking to the prostate, T cells transferred into Tg(TRAMP)8247Ng expressing mice do not exhibit cytolytic activity
decreased interferon-gamma secretion ( J:131347 )
• T cells transferred into Tg(TRAMP)8247Ng expressing mice express the activation marker CD44 but produce little to no IFN-gamma unlike similarly treated wild-type cells

hematopoietic system
abnormal T cell subpopulation ratio ( J:131347 )
• the CD4+ to CD8+ T cell ratio is shifted towards increased CD8+ T cells
decreased cytotoxic T cell cytolysis ( J:131347 )
• despite proliferation and trafficking to the prostate, T cells transferred into Tg(TRAMP)8247Ng expressing mice do not exhibit cytolytic activity




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory