Analysis Tools
cardiovascular system
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• under normoxic or hypoxic conditions, mice exhibit an increase in vascular permeability compared to wild-type mice
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homeostasis/metabolism
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• following exposure to hypoxic conditions, mice exhibit a greater increase in lung water, vascular leakiness and neutrophil accumulation compared to similarly treated wild-type mice even when wild-type bone marrow is transplanted into mice
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reproductive system
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• mice fail to exhibit corpus cavernosal smooth muscle relaxation in response to treatment with adenosine as do wild-type mice
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immune system
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• dendrictic cells generated from hematopoietic progenitor cells fail to exhibit increased production in VEGF, CXCL1 or IL6 in response to treatment with NECA as do wild-type cells
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• production reduced about 10% relative to controls in response to E coli and adenosine
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