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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxc1tm1Tsku
targeted mutation 1, Tsutomu Kume
MGI:3773756
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxc1tm1Tsku/Foxc1tm1Tsku involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL MGI:5443934
cn2
 		Foxc1tm1Tsku/Foxc1tm1Blh
Tg(Tek-cre)1Rwng/0 		involves: 129S6/SvEvTac * FVB/N MGI:3798681


Genotype
MGI:5443934
hm1
Allelic
Composition		 Foxc1tm1Tsku/Foxc1tm1Tsku
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Tsku mutation (0 available); any Foxc1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:188816 )
• mice appear normal, are fertile and are born in the expected Mendelian ratio




Genotype
MGI:3798681
cn2
Allelic
Composition		 Foxc1tm1Tsku/Foxc1tm1Blh
Tg(Tek-cre)1Rwng/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation (0 available); any Foxc1 mutation (29 available)
Foxc1tm1Tsku mutation (0 available); any Foxc1 mutation (29 available)
Tg(Tek-cre)1Rwng mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell migration ( J:131323 )
• isolated pulmonary microvascular endothelial cells exhibit a significant reduction in chemotactic migration towards Cxcl12




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory