All Phenotypes Tcra/Tcrd<tm1.1(Tcra)Rsky> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^b/H2^b Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807217
cx2	H2^b/H2^b Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807223
cx3	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807286
cx4	H2^d/H2^d Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807291

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 thymocytes from H2-D^b background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

Allelic Composition	H2^b/H2^b Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

hematopoietic system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

Allelic Composition	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (101 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	H2^d/H2^d Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

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