Analysis Tools|
Allele Symbol Allele Name Allele ID |
Zbtb7btm1Tani targeted mutation 1, Ichiro Taniuchi MGI:3774002 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• virtually all T cells found in the lymph node are double-positive T cells
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• virtually all T cells found in the lymph node are double-positive T cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the percentage of double negative thymocytes bearing Tcr-beta chains is doubled
• an unusual double negative T cell population is found in the lymph nodes of these mice
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• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
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• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+ T cells in vitro
• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+,or CD4+CD8+, or CD4-CD8- T cells when transferred into lymphocyte deficient hosts
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• single positive CD4+ T cell numbers are decreased in both in the thymus and lymph nodes
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• T-helper cells produce much less IL-4, have increased expression of IFN-gamma, and fail to express CD154 upon stimulation suggesting CD4 T cells from these mice have characteristics similar to CD8 T cells
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• the percentage of double negative thymocytes bearing Tcr-beta chains is doubled
• an unusual double negative T cell population is found in the lymph nodes of these mice
|
|
• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
|
|
• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+ T cells in vitro
• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+,or CD4+CD8+, or CD4-CD8- T cells when transferred into lymphocyte deficient hosts
|
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• single positive CD4+ T cell numbers are decreased in both in the thymus and lymph nodes
|
|
• T-helper cells produce much less IL-4, have increased expression of IFN-gamma, and fail to express CD154 upon stimulation suggesting CD4 T cells from these mice have characteristics similar to CD8 T cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• virtually all T cells found in the lymph node are double-positive T cells
|
|
• virtually all T cells found in the lymph node are double-positive T cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
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• CD8+ T cells are almost absent in the periphery
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• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
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• CD8+ T cells are almost absent in the periphery
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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