About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpc1tm1.1Alan
targeted mutation 1.1, Arthur Lander
MGI:3774029
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Foxn1nu/Foxn1nu
Gpc1tm1.1Alan/Gpc1tm1.1Alan 		involves: CD-1 MGI:3798863


Genotype
MGI:3798863
cx1
Allelic
Composition		 Foxn1nu/Foxn1nu
Gpc1tm1.1Alan/Gpc1tm1.1Alan
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (106 available)
Gpc1tm1.1Alan mutation (2 available); any Gpc1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:130809 )
• athymic mutants exhibit decreased tumor angiogenesis and metastasis following intrapancreatic implantation with either PANC-1 or T3M4 human pancreatic cancer cells and fewer pulmonary metastates following intravenous injection of murine B16-F10 melanoma cells

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:130809 )
• isolated hepatic endothelial cells exhibit an attenuated mitogenic response to VEGF-A, with cells showing a smaller increase in cell proliferation than wild-type in response to VEGF-A




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory