Phenotypes associated with this allele

• Allele Symbol: Tirap^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3774113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tirap^m1Btlr/Tirap^m1Btlr	C57BL/6J-Tirap^m1Btlr	MGI:3779056

Genotype
MGI:3779056

hm1

• Allelic Composition: Tirap^m1Btlr/Tirap^m1Btlr
• Genetic Background: C57BL/6J-Tirap^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal interferon secretion ( J:133618 )

• peritoneal macrophages from homozygous mutant mice produce reduced amounts of type I interferon (IFN) in response to lipopolysaccharide (LPS, a TLR4 ligand)

decreased tumor necrosis factor secretion ( J:133618 )

• peritoneal macrophages from homozygous torpid mice fail to produce tumor necrosis factor alpha (TNF-alpha) in response to standard challenge with peptidoglycan (a TLR2/1 ligand)

• homozygous mutant peritoneal macrophages fail to produce TNF-alpha in response to standard challenge with Pam3CSK4 (triacyl lipopeptide, a TLR2/6 ligand

• increasing the concentration of peptidoglycan or Pam3SK4 induces torpid macrophages to secrete a small quantity of TNF-alpha, indicating that TLR2 signaling is not completely abolished by this mutation

• TNF-alpha production by homozygous mutant macrophages is normal in response to oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs, a TLR9 ligand)

• torpid macrophages produce normal amounts of TNF-alpha in response to poly I:C (dsRNA mimic, a TLR3 ligand)

• homozygous mutant macrophages secrete normal quantities of TNF-alpha in response to resiquimod (a TLR7 ligand)