Phenotypes associated with this allele

• Allele Symbol: Sulf1^Gt(XM190)Byg
• Allele Name: gene trap XM190, BayGenomics
• Allele ID: MGI:3774126
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sulf1^Gt(XM190)Byg/Sulf1^Gt(XM190)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3812205
cx2	Shh^tm1Chg/Shh^+ Sulf1^Gt(XM190)Byg/Sulf1^Gt(XM190)Byg Sulf2^Gt(PST111)Byg/Sulf2^Gt(PST111)Byg	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10	MGI:3812210
cx3	Sulf1^Gt(XM190)Byg/Sulf1^+ Sulf2^Gt(PST111)Byg/Sulf2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3812207
cx4	Sulf1^Gt(XM190)Byg/Sulf1^Gt(XM190)Byg Sulf2^Gt(PST111)Byg/Sulf2^Gt(PST111)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3812208

Genotype
MGI:3812205

hm1

• Allelic Composition: Sulf1^Gt(XM190)Byg/Sulf1^Gt(XM190)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

sternebra fusion ( J:130163 )

• mice occasionally display partial fusion of sternebra 3 and 4

short sternum ( J:130163 )

• at E18.5, sternum length is decreased 93% of double heterozygotes

split vertebrae ( J:130163 )

• at P21, 71% of mice exhibit split dorsal vertebrae compared to 22% of wild-type mice with 14% of mice exhibiting involvement of 2 to 6 vertebrae

Genotype
MGI:3812210

cx2

• Allelic Composition: Shh^tm1Chg/Shh⁺; Sulf1^Gt(XM190)Byg/Sulf1^Gt(XM190)Byg; Sulf2^{Gt(PST111)Byg}/Sulf2^{Gt(PST111)Byg}
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

craniofacial

abnormal craniofacial morphology ( J:130163 )

• agnathic mice exhibit a narrow craniofacial region

absent mandible ( J:130163 )

• in 3 of 126 mice age E14.5 to E18.5

short mandible ( J:130163 )

• in 2 of 126 mice age E14.5 to E18.5

vision/eye

microphthalmia ( J:130163 )

• agnathic mice exhibit small or absent eyes

anophthalmia ( J:130163 )

• agnathic mice exhibit small or absent eyes

skeleton

absent mandible ( J:130163 )

• in 3 of 126 mice age E14.5 to E18.5

short mandible ( J:130163 )

• in 2 of 126 mice age E14.5 to E18.5

Genotype
MGI:3812207

cx3

• Allelic Composition: Sulf1^Gt(XM190)Byg/Sulf1⁺; Sulf2^{Gt(PST111)Byg}/Sulf2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

skeleton

sternebra fusion ( J:130163 )

• mice occasionally display partial fusion of sternebra 3 and 4

split vertebrae ( J:130163 )

• at P21, 75% of mice exhibit split dorsal vertebrae compared to 22% of wild-type mice

Genotype
MGI:3812208

cx4

• Allelic Composition: Sulf1^Gt(XM190)Byg/Sulf1^Gt(XM190)Byg; Sulf2^{Gt(PST111)Byg}/Sulf2^{Gt(PST111)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:130163 )

• 11% of mice die between weaning and 6 months of age

skeleton

abnormal skeleton morphology ( J:130163 )

• at P21, mice exhibit a smaller than normal skeleton

abnormal basisphenoid bone morphology ( J:130163 )

• 5 of 22 mice exhibit incomplete closure of the basisphenoid bone

long incisors ( J:130163 )

• some mice develop misaligned and over-grown incisors unlike in heterozygous mice

misaligned incisors ( J:130163 )

• some mice develop misaligned and over-grown incisors unlike in heterozygous mice

abnormal mandible morphology ( J:130163 )

• 2 of 29 mice exhibit fusion of the anterior tips of the left and right mandible

short radius ( J:130163 )

• at E16.5, radius length is 89% of double heterozygotes

• at E18.5, the length of the radius is decreased to 93% of double heterozygotes

• at P21, the length of the radius is reduced to 91% of wild-type

abnormal long bone epiphyseal plate proliferative zone ( J:130163 )

• at E16.5, mice exhibit a decrease in the length of the proliferating zone to 90% of double heterozygotes

• however, the ossified and hypertrophic zones were normal in length and there is no difference in the rate of proliferation within the zone

abnormal sternum morphology ( J:130163 )

• during development mice exhibit a reduction in the number of undifferentiated chondrocytes between sternebra 3 and 4 compared to in double heterozygotes indicating an acceleration of chondrocyte differentiation

sternebra fusion ( J:130163 )

• at E18.5, 85% of mice exhibit small bony bridges to broad connections between 2 or 3 sternebra

• at P0/P1, 100% of mice exhibit different degrees of sternebrae fusion that never involves more than 3 sternebrae

• 94% of mice exhibit fusion of sternebra 3 and 4 (65% complete) and 18% of mice exhibit a fusion of sternebra 2 and 3

short sternum ( J:130163 )

• at E18.5, sternum length is decreased 94% of double heterozygotes

• at P21, sternum length is decreased 87% of wild-type

wide sternum ( J:130163 )

• at P21, mice exhibit a broadened sternum compared to in wild-type mice

small thoracic cage ( J:130163 )

• at P21, mice exhibit a small ribcage

abnormal vertebral column morphology ( J:130163 )

caudal vertebral fusion ( J:130163 )

• after P21, 94% of mice exhibit calcified fusion of up to 7 distal tail vertebrae

abnormal cervical axis morphology ( J:130163 )

• 9 of 29 mice exhibit dorsally malformed second cervical vertebra

cervical vertebral transformation ( J:130163 )

• 3 mice exhibit transformation of C2 into C1

lumbar vertebral fusion ( J:130163 )

• at P0/P1, mice exhibit fusion of ossification centers in the lumbar vertebrae

sacral vertebral fusion ( J:130163 )

• at E18.5, 92% of mice exhibit connections in 1 to 5 vertebrae anterior to S2

• at P0/P1, all mice exhibit fusion of ossification centers in the sacral vertebrae

split vertebrae ( J:130163 )

• at P21, 88% of mice exhibit split dorsal vertebrae compared to 22% of wild-type mice with 47% of mice exhibiting involvement of 2 to 6 vertebrae

craniofacial

abnormal basisphenoid bone morphology ( J:130163 )

• 5 of 22 mice exhibit incomplete closure of the basisphenoid bone

long incisors ( J:130163 )

• some mice develop misaligned and over-grown incisors unlike in heterozygous mice

misaligned incisors ( J:130163 )

• some mice develop misaligned and over-grown incisors unlike in heterozygous mice

abnormal mandible morphology ( J:130163 )

• 2 of 29 mice exhibit fusion of the anterior tips of the left and right mandible

growth/size/body

long incisors ( J:130163 )

• some mice develop misaligned and over-grown incisors unlike in heterozygous mice

misaligned incisors ( J:130163 )

• some mice develop misaligned and over-grown incisors unlike in heterozygous mice

decreased body size ( J:130163 )

• at P21, occasionally strongly dwarfed mice are observed

decreased body weight ( J:130163 )

• at P0, body weight is reduced to 91% of double heterozygote weights

• at P21, mice weight 70% of double heterozygotes

• however, surviving mice recover to normal weight during postnatal development

limbs/digits/tail

short radius ( J:130163 )

• at E16.5, radius length is 89% of double heterozygotes

• at E18.5, the length of the radius is decreased to 93% of double heterozygotes

• at P21, the length of the radius is reduced to 91% of wild-type

caudal vertebral fusion ( J:130163 )

• after P21, 94% of mice exhibit calcified fusion of up to 7 distal tail vertebrae

kinked tail ( J:130163 )