Phenotypes associated with this allele

• Allele Symbol: Dtnbp1^sdy-Btlr
• Allele Name: sandy Bruce Beutler
• Allele ID: MGI:3774127
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dtnbp1^sdy-Btlr/Dtnbp1^sdy-Btlr	C57BL/6J-Dtnbp1^sdy-Btlr	MGI:3783301

Genotype
MGI:3783301

hm1

• Allelic Composition: Dtnbp1^sdy-Btlr/Dtnbp1^sdy-Btlr
• Genetic Background: C57BL/6J-Dtnbp1^sdy-Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:133620 )

• dilute coat color in homozygous mutant mice

immune system

impaired natural killer cell mediated cytotoxicity ( J:133620 )

• natural killer (NK) cells of homozygous mutant mice exhibit impaired cytotoxicity in vivo as measured by reduced clearance of MHC class 1-deficient cells

increased susceptibility to Herpesvirales infection ( J:133620 )

• homozygous mutant mice exhibit marked susceptibility to infection by mouse cytomegalovirus (MCMV)

integument

diluted coat color ( J:133620 )

• dilute coat color in homozygous mutant mice

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:133620 )

• natural killer (NK) cells of homozygous mutant mice exhibit impaired cytotoxicity in vivo as measured by reduced clearance of MHC class 1-deficient cells