All Phenotypes Rtn4r<tm1Gogo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rtn4r^tm1Gogo
targeted mutation 1, Joseph A Gogos
MGI:3774128

Summary

2 genotypes

Allelic Composition	Rtn4r^tm1Gogo/Rtn4r^tm1Gogo
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4r^tm1Gogo mutation (0 available); any Rtn4r mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:130368 )

N	• mice exhibit normal startle response, conditioned fear responses, and working memory in addition to not displaying behavioral despair • mice do not display schizophrenia-related behaviors

decreased vertical activity ( J:130368 )

• mice exhibit reduced vertical rearing in an open field test compared to wild-type mice

decreased locomotor activity ( J:130368 )

• mice travel reduced distances in an open field test compared to wild-type mice

• mice treated with an NMDA blocker (MK-801) exhibit decreased locomotor activity compared to similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	schizophrenia	DOID:5419	OMIM:181500	J:130368

Allelic Composition	Rtn4r^tm1Gogo/Rtn4r⁺
Genetic Background	involves: 129 * C57BL/6J