All Phenotypes Irak4<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irak4^m1Btlr
mutation 1, Bruce Beutler
MGI:3774129

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irak4^m1Btlr/Irak4^m1Btlr	C57BL/6J-Irak4^m1Btlr	MGI:3778301
cx2	Irak4^m1Btlr/Irak4^m1Btlr Ptpn6^m1Btlr/Ptpn6^m1Btlr	C57BL/6J-Ptpn6^m1Btlr Irak4^m1Btlr	MGI:3822470
cx3	Irak4^m1Btlr/Irak4^m1Btlr Ticam1^Lps2/Ticam1^Lps2	involves: C57BL/6J	MGI:5437490

Allelic Composition	Irak4^m1Btlr/Irak4^m1Btlr
Genetic Background	C57BL/6J-Irak4^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak4^m1Btlr mutation (2 available); any Irak4 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased tumor necrosis factor secretion ( J:133271 )

• peritoneal macrophages from mice homozygous for this mutation fail to produce tumor necrosis factor- (TNF-) alpha in response to unmethylated CpG DNA, a TLR9 ligand

• peritoneal macrophages from homozygous mutant mice fail to produce TNF-alpha in response to resiquimod, a TLR7 ligand

• peritoneal macrophages from homozygous mutant mice fail to produce TNF-alpha in response to triacyl lipopeptides, TLR2/1 ligands

• peritoneal macrophages from homozygous mutant mice fail to produce TNF-alpha in response to peptidoglycans, TLR2/6 ligands

• lipopolysaccharide, a ligand of TLR4, stimulates production by mutant macrophages of detectable but significantly reduced amounts of TNF-alpha

• homozygous mutant macrophages produce normal amounts of TNF-alpha in response to poly I:C, a TLR3 ligand

Allelic Composition	Irak4^m1Btlr/Irak4^m1Btlr Ptpn6^m1Btlr/Ptpn6^m1Btlr
Genetic Background	C57BL/6J-Ptpn6^m1Btlr Irak4^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak4^m1Btlr mutation (2 available); any Irak4 mutation (32 available)
Ptpn6^m1Btlr mutation (1 available); any Ptpn6 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:142845 )

N	• the plantar inflammation that is a phenotypic characteristic for Ptpn6^m1Btlr homozygotes are not found in these mice

Allelic Composition	Irak4^m1Btlr/Irak4^m1Btlr Ticam1^Lps2/Ticam1^Lps2
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak4^m1Btlr mutation (2 available); any Irak4 mutation (32 available)
Ticam1^Lps2 mutation (2 available); any Ticam1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased tumor necrosis factor secretion ( J:187583 )

• peritoneal macrophage fail to exhibit a TLR-induced TNFalpha response

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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