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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr96tm1Yzo
targeted mutation 1, Yong-Rui Zou
MGI:3774141
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr96tm1Yzo/Rr96tm1Yzo involves: 129P2/OlaHsd MGI:3808862
cn2
 		Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd8a-cre,-GFP)1Yzo/? 		involves: 129P2/OlaHsd MGI:3808867
cn3
 		Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd4-cre)1Cwi/? 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3808865


Genotype
MGI:3808862
hm1
Allelic
Composition		 Rr96tm1Yzo/Rr96tm1Yzo
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:130559 )
• mice are viable and fertile
• mice have normal expression of CD4 in developing and mature T cells




Genotype
MGI:3808867
cn2
Allelic
Composition		 Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd8a-cre,-GFP)1Yzo/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-positive T cell number ( J:130559 )
• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis

hematopoietic system
increased double-positive T cell number ( J:130559 )
• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis




Genotype
MGI:3808865
cn3
Allelic
Composition		 Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm1Yzo mutation (0 available); any Rr96 mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:130559 )
• CD4 silencing is defective in these mice leading to expression of CD4 on cytotoxic T cells that normally only express CD8
• these peripheral double positive T cells have the cytotoxic effector functions of CD8+ T cells
increased double-positive T cell number ( J:130559 )
• all peripheral CD8+ T cells co-express CD4 leading to a large increase in double positive numbers in the spleen

hematopoietic system
abnormal T cell differentiation ( J:130559 )
• CD4 silencing is defective in these mice leading to expression of CD4 on cytotoxic T cells that normally only express CD8
• these peripheral double positive T cells have the cytotoxic effector functions of CD8+ T cells
increased double-positive T cell number ( J:130559 )
• all peripheral CD8+ T cells co-express CD4 leading to a large increase in double positive numbers in the spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory