All Phenotypes Rr96<tm1.1Yzo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr96^tm1.1Yzo/Rr96^tm1.1Yzo	involves: 129P2/OlaHsd	MGI:3808858
cx2	B2m^tm1Jae/B2m^tm1Jae Rr96^tm1.1Yzo/Rr96^tm1.1Yzo	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3808859
cx3	Rr96^tm1.1Yzo/Rr96^tm1.1Yzo H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3808861

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:130559 )

• CD4 silencing is defective in these mice leading to premature expression of CD4 in T-cell precursors and expression of CD4 on cytotoxic T cells that normally only express CD8

• these peripheral double positive T cells have the cytotoxic effector functions of CD8⁺ T cells

increased double-positive T cell number ( J:130559 )

• all CD8⁺ T cells co-express CD4 leading to a slight increase in double positive numbers in the thymus and large increase in numbers in the spleen

increased CD4-positive, alpha-beta T cell number ( J:130559 )

• percentage of CD4 single positive T cells are slightly increased in the thymus

hematopoietic system

abnormal T cell differentiation ( J:130559 )

• CD4 silencing is defective in these mice leading to premature expression of CD4 in T-cell precursors and expression of CD4 on cytotoxic T cells that normally only express CD8

• these peripheral double positive T cells have the cytotoxic effector functions of CD8⁺ T cells

increased double-positive T cell number ( J:130559 )

• all CD8⁺ T cells co-express CD4 leading to a slight increase in double positive numbers in the thymus and large increase in numbers in the spleen

increased CD4-positive, alpha-beta T cell number ( J:130559 )

• percentage of CD4 single positive T cells are slightly increased in the thymus

Allelic Composition	B2m^tm1Jae/B2m^tm1Jae Rr96^tm1.1Yzo/Rr96^tm1.1Yzo
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Jae mutation (8 available); any B2m mutation (122 available)
Rr96^tm1.1Yzo mutation (0 available); any Rr96 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are absent in these mice demonstrating Class I-dependence of this cell population

hematopoietic system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are absent in these mice demonstrating Class I-dependence of this cell population

Allelic Composition	Rr96^tm1.1Yzo/Rr96^tm1.1Yzo H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1^b-tm1Gru mutation (11 available); any H2-Ab1 mutation (83 available)
Rr96^tm1.1Yzo mutation (0 available); any Rr96 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are also present in these mice demonstrating Class II-independence of this cell population

hematopoietic system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are also present in these mice demonstrating Class II-independence of this cell population

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24