All Phenotypes Rr96<tm1.1Yzo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr96^tm1.1Yzo/Rr96^tm1.1Yzo	involves: 129P2/OlaHsd	MGI:3808858
cx2	B2m^tm1Jae/B2m^tm1Jae Rr96^tm1.1Yzo/Rr96^tm1.1Yzo	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3808859
cx3	Rr96^tm1.1Yzo/Rr96^tm1.1Yzo H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3808861

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:130559 )

• CD4 silencing is defective in these mice leading to premature expression of CD4 in T-cell precursors and expression of CD4 on cytotoxic T cells that normally only express CD8

• these peripheral double positive T cells have the cytotoxic effector functions of CD8⁺ T cells

increased double-positive T cell number ( J:130559 )

• all CD8⁺ T cells co-express CD4 leading to a slight increase in double positive numbers in the thymus and large increase in numbers in the spleen

increased CD4-positive, alpha-beta T cell number ( J:130559 )

• percentage of CD4 single positive T cells are slightly increased in the thymus

hematopoietic system

abnormal T cell differentiation ( J:130559 )

• CD4 silencing is defective in these mice leading to premature expression of CD4 in T-cell precursors and expression of CD4 on cytotoxic T cells that normally only express CD8

• these peripheral double positive T cells have the cytotoxic effector functions of CD8⁺ T cells

increased double-positive T cell number ( J:130559 )

• all CD8⁺ T cells co-express CD4 leading to a slight increase in double positive numbers in the thymus and large increase in numbers in the spleen

increased CD4-positive, alpha-beta T cell number ( J:130559 )

• percentage of CD4 single positive T cells are slightly increased in the thymus

Allelic Composition	B2m^tm1Jae/B2m^tm1Jae Rr96^tm1.1Yzo/Rr96^tm1.1Yzo
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Jae mutation (8 available); any B2m mutation (121 available)
Rr96^tm1.1Yzo mutation (0 available); any Rr96 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are absent in these mice demonstrating Class I-dependence of this cell population

hematopoietic system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are absent in these mice demonstrating Class I-dependence of this cell population

Allelic Composition	Rr96^tm1.1Yzo/Rr96^tm1.1Yzo H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1^b-tm1Gru mutation (11 available); any H2-Ab1 mutation (82 available)
Rr96^tm1.1Yzo mutation (0 available); any Rr96 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are also present in these mice demonstrating Class II-independence of this cell population

hematopoietic system

abnormal T cell differentiation ( J:130559 )

• the peripheral CD4⁺CD8⁺ double positive T cells observed in Cd4^tm1.1Yzo homozygotes are also present in these mice demonstrating Class II-independence of this cell population

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