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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cd8a-cre,-GFP)1Yzo
transgene insertion 1, Yong-Rui Zou
MGI:3774145
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd8a-cre,-GFP)1Yzo/? 		involves: 129P2/OlaHsd MGI:3808867
cn2
 		Laynem1Romd/Laynem1Romd
Tg(Cd8a-cre,-GFP)1Yzo/0 		involves: C57BL/6 MGI:6693356


Genotype
MGI:3808867
cn1
Allelic
Composition		 Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd8a-cre,-GFP)1Yzo/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-positive T cell number ( J:130559 )
• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis

hematopoietic system
increased double-positive T cell number ( J:130559 )
• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis




Genotype
MGI:6693356
cn2
Allelic
Composition		 Laynem1Romd/Laynem1Romd
Tg(Cd8a-cre,-GFP)1Yzo/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Laynem1Romd mutation (0 available); any Layn mutation (21 available)
Tg(Cd8a-cre,-GFP)1Yzo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:302853 )
N
• display normal frequencies of CD8+ cells across multiple organs
abnormal CD8-positive, alpha-beta T cell physiology ( J:302853 )
• when transplanted into Rag2 null hosts that are then transplanted with MC38 adenocarcinoma cells there is a marked reduction in the accumulation of cells first in the tumor and then in secondary lymphoid organs

neoplasm
increased tumor growth/size ( J:302853 )
• enhanced growth of tumors developing from transplanted B16-F10 melanoma or MC38 adenocarcinoma cells

hematopoietic system
abnormal CD8-positive, alpha-beta T cell physiology ( J:302853 )
• when transplanted into Rag2 null hosts that are then transplanted with MC38 adenocarcinoma cells there is a marked reduction in the accumulation of cells first in the tumor and then in secondary lymphoid organs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory