About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cd8a-cre,-GFP)1Yzo
transgene insertion 1, Yong-Rui Zou
MGI:3774145
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd8a-cre,-GFP)1Yzo/? 		involves: 129P2/OlaHsd MGI:3808867
cn2
 		Laynem1Romd/Laynem1Romd
Tg(Cd8a-cre,-GFP)1Yzo/0 		involves: C57BL/6 MGI:6693356


Genotype
MGI:3808867
cn1
Allelic
Composition		 Rr96tm1Yzo/Rr96tm1Yzo
Tg(Cd8a-cre,-GFP)1Yzo/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-positive T cell number ( J:130559 )
• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis

hematopoietic system
increased double-positive T cell number ( J:130559 )
• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis




Genotype
MGI:6693356
cn2
Allelic
Composition		 Laynem1Romd/Laynem1Romd
Tg(Cd8a-cre,-GFP)1Yzo/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Laynem1Romd mutation (0 available); any Layn mutation (22 available)
Tg(Cd8a-cre,-GFP)1Yzo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:302853 )
N
• display normal frequencies of CD8+ cells across multiple organs
abnormal CD8-positive, alpha-beta T cell physiology ( J:302853 )
• when transplanted into Rag2 null hosts that are then transplanted with MC38 adenocarcinoma cells there is a marked reduction in the accumulation of cells first in the tumor and then in secondary lymphoid organs

neoplasm
increased tumor growth/size ( J:302853 )
• enhanced growth of tumors developing from transplanted B16-F10 melanoma or MC38 adenocarcinoma cells

hematopoietic system
abnormal CD8-positive, alpha-beta T cell physiology ( J:302853 )
• when transplanted into Rag2 null hosts that are then transplanted with MC38 adenocarcinoma cells there is a marked reduction in the accumulation of cells first in the tumor and then in secondary lymphoid organs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory