Analysis Tools
nervous system
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• at 16 weeks of age, concentration of the aspartoacylase substrate N-acetyl-L-aspartate (NAA) in brain in tamoxifen-treated mice is 55% below that in tamoxifen-treated control homozygous Aspanur7 mice, indicating partial reversal of increased brain NAA levels seen in Canavan disease model Aspanur7 mice
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• the extent of cerebellar vacuolation in tamoxifen-treated mice is not different from that seen in homozygous Aspanur7 mice
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behavior/neurological
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• accelerating rotarod retention time is increased by 1 week after completion of tamoxifen administration and remains elevated through 7 additional weeks compared to homozygous Aspanur7 mice, indicating improved motor function
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