All Phenotypes Cstf2t<tm1Ccma> MGI Mouse

reproductive system phenotype ( J:130584 )

N	• males show no differences in size or weight of testes, epididymides or accessory reproductive organs at the stages of postnatal development examined

oligozoospermia ( J:130584 )

• reduced number of normal spermatozoa in epididymis; cauda epididymal contents show males have bout 10% of number of spermatozoa found in wild-type or heterozygous males

teratozoospermia ( J:130584 )

globozoospermia ( J:130584 )

• large number of round cells observed with reduced number of mature spermatozoa in cauda epididyma

abnormal spermatid morphology ( J:130584 )

• defects are seen in step-10 spermatid heads, including abnormal head structures, accumulation of cytoplasmic lobes and residual bodies, and fusions of these bodies with the spermatid tails; defects increase in number as spermiogenesis progresses

asthenozoospermia ( J:130584 )

• number of motile sperm is reduced >10-fold; progressivity, amplitude of lateral head displacement, curvilinear and linear velocities are all significantly reduced compared to littermates

abnormal spermiogenesis ( J:130584 )

abnormal spermiation ( J:130584 )

• spermiation fails, such that step-16 mature spermatids are present beyond stage VIII

male infertility ( J:130584 )

• males are infertile whereas females and heterozygotes of both sexes show normal fertility

impaired fertilization ( J:130584 )

• males show normal mating behavior and vaginal plugs are observed in females, but at 3 days postcoitum, oocytes flushed from oviducts do not show signs of normal cleavage (indicating fertilization); oocytes instead show degeneration ranging from failure to progress from one-cell stage to granulation and empty cells