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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Akr1c18tm1Mni
targeted mutation 1, Masugi Nishihara
MGI:3774264
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Akr1c18tm1Mni/Akr1c18tm1Mni involves: 129P2/OlaHsd * C57BL/6J MGI:3800787


Genotype
MGI:3800787
hm1
Allelic
Composition
Akr1c18tm1Mni/Akr1c18tm1Mni
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1c18tm1Mni mutation (2 available); any Akr1c18 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• pregnancy is prolonged by 2 days in 2 of 11 mutants and by 1 day in 3 mutants and pseudopregnancy is extended by 2.5 days
• duration of continuous diestrus is prolonged by about 1.5 days
• the number of pups, especially live pups, is decreased

homeostasis/metabolism
• serum progesterone levels do decline before parturition as in wild-type and are low enough for delivery of pups, however levels are still 1.3 times higher than in wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory