Phenotypes associated with this allele

• Allele Symbol: Wdtc1^{Gt(RRF015)Byg}
• Allele Name: gene trap RRF015, BayGenomics
• Allele ID: MGI:3774270
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdtc1^Gt(RRF015)Byg/Wdtc1^Gt(RRF015)Byg	involves: 129P2/OlaHsd * ICR	MGI:3800818
ht2	Wdtc1^Gt(RRF015)Byg/Wdtc1^+	involves: 129P2/OlaHsd * ICR	MGI:3800819

Genotype
MGI:3800818

hm1

• Allelic Composition: Wdtc1^{Gt(RRF015)Byg}/Wdtc1^{Gt(RRF015)Byg}
• Genetic Background: involves: 129P2/OlaHsd * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:129966 )

• less than the expected numbers of homozygotes are born

growth/size/body

obese ( J:129966 )

• some homozygotes are obese

Genotype
MGI:3800819

ht2

• Allelic Composition: Wdtc1^{Gt(RRF015)Byg}/Wdtc1⁺
• Genetic Background: involves: 129P2/OlaHsd * ICR

adipose tissue

increased fat cell size ( J:129966 )

growth/size/body

obese ( J:129966 )

homeostasis/metabolism

increased circulating glucose level ( J:129966 )

• heterozygotes have a trend towards hyperglycemia during glucose tolerance tests, however this is not often significant

increased circulating insulin level ( J:129966 )

increased circulating leptin level ( J:129966 )

insulin resistance ( J:129966 )