Phenotypes associated with this allele

• Allele Symbol: Eif2ak3^tm1.1Drc
• Allele Name: targeted mutation 1.1, Douglas R Cavener
• Allele ID: MGI:3774276
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc Tg(Ela1-cre)16Eps/0	involves: 129S6/SvEvTac	MGI:3777111

Genotype
MGI:3777111

cn1

• Allelic Composition: Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc; Tg(Ela1-cre)16Eps/0
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Acinar cells are lost in both Eif2ak3^tm1Drc/Eif2ak3^tm1Drc and Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc Tg(Ela1-cre)16Eps/0 mice

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:129974 )

• at 3 weeks after birth, the exocrine pancreas shows structural disorganization and cell death

abnormal pancreatic acinus morphology ( J:129974 )

• extensive acinar cell death is seen by P25 and by 3-4 months of age, acinar cells are no longer the major cell type of the exocrine pancreas and are replaced by fibroblasts, adipocytes, and macrophages/leukocytes

• a subset of severely affected mutants appear to have dedifferentiation of acini into duct-like structures in lieu of the cell death seen in most mutants

abnormal pancreatic acinar cell morphology ( J:129974 )

• acinar cells show no evidence of ER-stress and die through oncosis and not apoptosis, as indicated by vacuolation followed by karyolysis and loss of plasma membrane integrity

exocrine pancreas atrophy ( J:129974 )

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:129974 )

• at 3 weeks after birth, the exocrine pancreas shows structural disorganization and cell death

abnormal pancreatic acinus morphology ( J:129974 )

• extensive acinar cell death is seen by P25 and by 3-4 months of age, acinar cells are no longer the major cell type of the exocrine pancreas and are replaced by fibroblasts, adipocytes, and macrophages/leukocytes

• a subset of severely affected mutants appear to have dedifferentiation of acini into duct-like structures in lieu of the cell death seen in most mutants

abnormal pancreatic acinar cell morphology ( J:129974 )

• acinar cells show no evidence of ER-stress and die through oncosis and not apoptosis, as indicated by vacuolation followed by karyolysis and loss of plasma membrane integrity

exocrine pancreas atrophy ( J:129974 )

small pancreas ( J:129974 )

• size of pancreatic mass decreases with age due to extensive acinar cell death

acute pancreas inflammation ( J:129974 )

• develop acute pancreatitis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:129974 )

N • mutants do not become diabetic and exhibit normal glucose clearance rates when subjected to glucose tolerance tests

increased circulating amylase level ( J:129974 )

• serum amylase is elevated as early as P18, an indication of pancreatitis

immune system

acute pancreas inflammation ( J:129974 )

• develop acute pancreatitis