Phenotypes associated with this allele

• Allele Symbol: Nr1h4^tm1.1Gonz
• Allele Name: targeted mutation 1.1, Frank Gonzalez
• Allele ID: MGI:3774280
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz Tg(Alb1-cre)1Dlr/0	involves: 129X1/SvJ * C57BL/6	MGI:3806162
cn2	Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz Tg(Vil1-cre)997Gum/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:3806161

Genotype
MGI:3806162

cn1

• Allelic Composition: Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz; Tg(Alb1-cre)1Dlr/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:129978 )

• serum cholesterol levels are elevated by about 50%

increased circulating triglyceride level ( J:129978 )

• serum triglyceride levels are significantly higher than in control mice

increased bile salt level ( J:129978 )

• serum bile acids are greatly elevated in these mice

• total bile acid pool collected from liver, gallbladder and small intestine is significantly higher than in controls

• the increases in the bile acid pool consist of increases in cholate and its derivates including taurocholic acid and taurodeoxycholic acid

Genotype
MGI:3806161

cn2

• Allelic Composition: Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

homeostasis/metabolism

abnormal bile salt homeostasis ( J:129978 )

• mice have almost double the loss of deoxycholic acid in the feces compared to control mice

increased bile salt level ( J:129978 )

• total bile acid pool collected from liver, gallbladder and small intestine trends towards being higher than in controls

• the increases in the bile acid pool consist of increases in cholate and its derivates including taurocholic acid and taurodeoxycholic acid