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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp5r18
r18
MGI:3774282
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp5r18/Lrp5r18 C57BL/6J-Lrp5r18 MGI:3806486


Genotype
MGI:3806486
hm1
Allelic
Composition		 Lrp5r18/Lrp5r18
Genetic
Background		 C57BL/6J-Lrp5r18
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5r18 mutation (0 available); any Lrp5 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:135279 )
• hyperpermeable retinal vessels
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development
• immature endothelial cells in lumen-less capillaries are associated with an attenuated vessel network

vision/eye
abnormal retina vasculature morphology ( J:135279 )
• hyperpermeable retinal vessels
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development
• immature endothelial cells in lumen-less capillaries are associated with an attenuated vessel network

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
exudative vitreoretinopathy DOID:0050535 OMIM:PS133780
 J:135279




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory