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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pdx1-Ffar1)AHeed
transgene insertion A, Helena Edlund
MGI:3774304
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Pdx1-Ffar1)AHeed/0 Not Specified MGI:3806273


Genotype
MGI:3806273
tg1
Allelic
Composition
Tg(Pdx1-Ffar1)AHeed/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice have a loss of first-phase insulin release and a severely blunted second-phase insulin release during tolerance tests
• mice are glucose intolerant with blood glucose levels being significantly higher and remaining high longer than in non-transgenic controls

endocrine/exocrine glands
• the alpha cells are distributed throughout the islets instead of on the periphery
• total insulin content in the pancreas is about half that of wild-type pancreas while gene transcript levels for insulin are normal
• mice have a loss of first-phase insulin release and a severely blunted second-phase insulin release during tolerance tests





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory