All Phenotypes Gfra1<tm3Jmi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gfra1^tm3Jmi
targeted mutation 3, Jeffrey Milbrandt
MGI:3774317

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfra1^tm3Jmi/Gfra1^tm3Jmi	involves: 129X1/SvJ	MGI:3783342
cn2	Erbb2^tm1Haus/Erbb2^tm1Klee Gfra1^tm3Jmi/Gfra1⁺ Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ	MGI:4456175
cn3	Gfra1^tm2Jmi/Gfra1^tm3Jmi Tg(Hoxb7-cre)13Amc/0	involves: 129X1/SvJ * C57BL/6	MGI:5514419
cx4	Egr3^tm1Jmi/Egr3^tm1Jmi Gfra1^tm3Jmi/Gfra1⁺	involves: 129X1/SvJ	MGI:4456173
cx5	Gfra1^tm3Jmi/Gfra1^tm3Jmi Ret^{tm14(Gfra1)Jmi}/Ret⁺	involves: 129X1/SvJ	MGI:3801035
cx6	Egr3^tm1Jmi/Egr3^tm1Jmi Gfra1^tm3Jmi/Gfra1⁺ Tg(Hlxb9-GFP)1Tmj/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:4456172

Allelic Composition	Gfra1^tm3Jmi/Gfra1^tm3Jmi
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra1^tm3Jmi mutation (0 available); any Gfra1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:130616 )

• all homozygotes die perinatally

nervous system

abnormal nervous system morphology ( J:130616 )

• arborized branches of the brachial nerves that target the latissimus dorsi and cutaneous maximus muscles are lost in embryos

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• however, muscle spindle innervation is normal in Rectus femoris

absent enteric neurons ( J:130616 )

• loss of enteric neurons is seen as early as E10.5

• loss of esophageal enteric neurons in newborns

abnormal motor neuron morphology ( J:130616 )

• majority of PEA3+ motor neurons (detected as Islet1+HB9+ cells) in the spinal cord are shifted dorsally in mutant embryos

abnormal motor neuron innervation pattern ( J:132854 )

• motor innervation to superior gluteus maximus and tensor facia latae is disrupted

• lack innervation to posterior Psoas major

decreased motor neuron number ( J:132854 )

• loss of more than 20% of motor neurons at the lumbar level

• elevated apoptosis of motor neurons between 13.5 and E15.5

renal/urinary system

absent kidney ( J:130616 )

• loss of kidneys is seen as early as E11.5

impaired branching involved in ureteric bud morphogenesis ( J:130616 )

• ureteric bud in embryos fails to grow out from the Wolffian duct or to branch properly

muscle

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• however, muscle spindle innervation is normal in Rectus femoris

Allelic Composition	Erbb2^tm1Haus/Erbb2^tm1Klee Gfra1^tm3Jmi/Gfra1⁺ Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (61 available)
Erbb2^tm1Klee mutation (0 available); any Erbb2 mutation (61 available)
Gfra1^tm3Jmi mutation (0 available); any Gfra1 mutation (33 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cholinergic neuron morphology ( J:160727 )

• the number of cholinergic motor neurons is decreased compared to in wild-type mice

decreased motor neuron number ( J:160727 )

• the number of cholinergic motor neurons is decreased compared to in wild-type mice

• mice exhibit a reduction in small Gfra1+ motor neurons compared with wild-type mice

• loss of gamma-motor neurons is intermediate to wild-type mice and Egr3^tm1Jmi homozygotes

• mice exhibit a decrease in large diameter motor neurons compared with wild-type mice

Allelic Composition	Gfra1^tm2Jmi/Gfra1^tm3Jmi Tg(Hoxb7-cre)13Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra1^tm2Jmi mutation (0 available); any Gfra1 mutation (33 available)
Gfra1^tm3Jmi mutation (0 available); any Gfra1 mutation (33 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

absent kidney ( J:199323 )

• at P0, most have bilateral kidney agenesis/aplasia (16/20)

single kidney ( J:199323 )

• at P0, a few pups (3/20) have unilateral kidney agenesis and contralateral megaureter

large ureter ( J:199323 )

• at P0, a few pups (3/20) have unilateral kidney agenesis and contralateral megaureter

Allelic Composition	Egr3^tm1Jmi/Egr3^tm1Jmi Gfra1^tm3Jmi/Gfra1⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3^tm1Jmi mutation (2 available); any Egr3 mutation (17 available)
Gfra1^tm3Jmi mutation (0 available); any Gfra1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cholinergic neuron morphology ( J:160727 )

• mice exhibit selective loss of small cholinergic neurons unlike wild-type mice

• total numbers of cholinergic neurons in the L4-5 section of the spinal cord is decreased compared to in wild-type mice

decreased motor neuron number ( J:160727 )

• total numbers of cholinergic neurons in the L4-5 section of the spinal cord is decreased compared to in wild-type mice

Allelic Composition	Gfra1^tm3Jmi/Gfra1^tm3Jmi Ret^{tm14(Gfra1)Jmi}/Ret⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra1^tm3Jmi mutation (0 available); any Gfra1 mutation (33 available)
Ret^{tm14(Gfra1)Jmi} mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:130616 )

• mutants exhibit no deficits in enteric neurons, motor neurons, Schwann cells, regenerating nerves, ureteric bud and kidney development and no abnormalities in the olfactory bulb

Allelic Composition	Egr3^tm1Jmi/Egr3^tm1Jmi Gfra1^tm3Jmi/Gfra1⁺ Tg(Hlxb9-GFP)1Tmj/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cholinergic neuron morphology ( J:160727 )

• mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice

abnormal motor neuron morphology ( J:160727 )

• surviving Gfra1+ motor neurons exhibit somatic shrinkage and morphological evidence of degeneration unlike in wild-type mice

decreased motor neuron number ( J:160727 )

• Gfra1+, cholinergic, Gfa1+ HB9-GFP-, and Gfra1+ HB9-GFP+ motor neurons are reduced compared to in wild-type mice

• mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice

• however, the number of large diameter motor neurons is normal

motor neuron degeneration ( J:160727 )

• surviving Gfra1+ motor neurons exhibit somatic shrinkage and morphological evidence of degeneration unlike in wild-type mice

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