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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Eif2ak4tm1.1Dron
targeted mutation 1.1, David Ron
MGI:3774318
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Eif2ak4tm1.1Dron/Eif2ak4tm1.1Dron
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3806277


Genotype
MGI:3806277
cn1
Allelic
Composition
Eif2ak4tm1.1Dron/Eif2ak4tm1.1Dron
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4tm1.1Dron mutation (1 available); any Eif2ak4 mutation (89 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice have much less of an aversion to diets lacking an essential amino acid
• mice consume more of a leucine-deficient chow after 1 hour compared to wild-type mice that consume almost 30% less
• mice consume under 10% less leucine-deficient chow after 4 hours compared to wild-type mice that consume around 25% less
• similar responses are observed in threonine-deficient diet





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory