Phenotypes associated with this allele

• Allele Symbol: Ntrk2^tm1Mini
• Allele Name: targeted mutation 1, Liliana Minichiello
• Allele ID: MGI:3774320
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm1Mini/Ntrk2^tm1Mini	involves: 129P2/OlaHsd	MGI:3806578
ht2	Ntrk2^tm1Mini/Ntrk2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5575866

Genotype
MGI:3806578

hm1

• Allelic Composition: Ntrk2^tm1Mini/Ntrk2^tm1Mini
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired synaptic plasticity ( J:130626 )

• basal synaptic transmission is normal but synaptic strengthening is impaired as evidenced by abnormal long term potentiation

abnormal excitatory postsynaptic potential ( J:130626 )

• mean EPSP slope as a percentage of baseline is 125.7% compared to 148.1% in controls

• mean EPSP slope in long-lasting LTP as a percentage of baseline is 116.1% compared to 133.5% in controls

abnormal long-term potentiation ( J:130626 )

• there is a reduced induction rate of LTP in hippocampal slices

• induction (measured as a signal 20% above baseline) only occurs 37.5% of the time after burst stimulation compared to 70% in controls

• similar results are observed after tetanus application

• impairment also occurs after long-lasting LTP (L-LTP) tested by repeated theta burst

• L-LTP induction rate is 30.8% compared to 62.5% and does not improve with increased stimulus strength

Genotype
MGI:5575866

ht2

• Allelic Composition: Ntrk2^tm1Mini/Ntrk2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

growth/size/body

increased susceptibility to age related obesity ( J:210229 )

• mature mice (2-3 months) become obese

behavior/neurological

behavior/neurological phenotype ( J:210229 )

N • no difference in cumulative food intake by 7 month-old mice is observed during a 3 week period

adipose tissue

increased abdominal fat pad weight ( J:210229 )

homeostasis/metabolism

increased circulating insulin level ( J:210229 )

• elevated in older (5 months) mice

increased circulating leptin level ( J:210229 )

• elevated in older (5 months) mice

increased circulating adrenocorticotropin level ( J:210229 )

• ACTH levels are significantly elevated in 5 month animals at 4pm relative to controls

endocrine/exocrine glands

increased adrenal gland zona fasciculata size ( J:210229 )

• thicker at 5 months

adrenal cortical hyperplasia ( J:210229 )

• at 5 months

liver/biliary system

abnormal liver morphology ( J:210229 )

• mice show increase hepatic lipid accumulation compared to controls