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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja8L1
lens mutation 1
MGI:3774321
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gja8L1/Gja8L1 involves: C3H/HeJ * C57BL/6J MGI:3811918
ht2
 		Gja8L1/Gja8+ involves: C3H/HeJ * C57BL/6J MGI:3811919
ht3
 		Gja8L1/Gja8tm1Scr involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3811921
cx4
 		Gja3tm1Scr/Gja3tm1Scr
Gja8L1/Gja8tm1Scr 		involves: 129 * C3H/HeJ * C57BL/6J MGI:3811922
cx5
 		Gja3tm1Scr/Gja3tm1Scr
Gja8L1/Gja8+ 		involves: 129S4/SvJae * C3H/HeJ * C57BL/6J MGI:3811920


Genotype
MGI:3811918
hm1
Allelic
Composition		 Gja8L1/Gja8L1
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8L1 mutation (1 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
ruptured lens capsule ( J:108522 )
• posterior capsule ruptures
lens vacuoles ( J:108522 )
• vacuole formation
abnormal lens fiber morphology ( J:108522 )
• disorganized
• large cystic lumen forms between posterior primary fiber cells and anterior epithelium at E15.5
• primary fiber cells fail to elongate normally




Genotype
MGI:3811919
ht2
Allelic
Composition		 Gja8L1/Gja8+
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8L1 mutation (1 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
ruptured lens capsule ( J:108522 )
• posterior capsule ruptures
lens vacuoles ( J:108522 )
• vacuole formation
microphthalmia ( J:108522 )
• eyes are 30% the size of controls at weaning




Genotype
MGI:3811921
ht3
Allelic
Composition		 Gja8L1/Gja8tm1Scr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:108522 )
N
• lack cysts in lens
total cataract ( J:108522 )
• whole cataracts




Genotype
MGI:3811922
cx4
Allelic
Composition		 Gja3tm1Scr/Gja3tm1Scr
Gja8L1/Gja8tm1Scr
Genetic
Background		 involves: 129 * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:108522 )
N
• normal lens fiber cell elongation
nuclear cataract ( J:108522 )
• large nuclear cataracts 3 weeks of age




Genotype
MGI:3811920
cx5
Allelic
Composition		 Gja3tm1Scr/Gja3tm1Scr
Gja8L1/Gja8+
Genetic
Background		 involves: 129S4/SvJae * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8L1 mutation (1 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens morphology ( J:108522 )
• cystic lumen
nuclear cataract ( J:108522 )
• nuclear rather than whole cataracts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory