Phenotypes associated with this allele

• Allele Symbol: Kcnk9^tm1.1Daba
• Allele Name: targeted mutation 1.1, Douglas A Bayliss
• Allele ID: MGI:3774332
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk9^tm1.1Daba/Kcnk9^tm1.1Daba	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3806600
cx2	Kcnk3^tm1.1Daba/Kcnk3^tm1.1Daba Kcnk9^tm1.1Daba/Kcnk9^tm1.1Daba	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3806597
cx3	Kcnk3^tm1.1Daba/Kcnk3^tm1.1Daba Kcnk9^tm1.1Daba/Kcnk9^tm1.1Daba	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3796531

Genotype
MGI:3806600

hm1

• Allelic Composition: Kcnk9^tm1.1Daba/Kcnk9^tm1.1Daba
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:130850 )

N • no abnormalities were found in the pH sensitivity of neurons in the retrotrapezoid nucleus

abnormal action potential ( J:130850 )

• serotonergic neurons within the raphe nucleus lack pH dependent-changes in discharge

• wild-type firing rates decrease from 1.2 Hz to 0.5 Hz over a pH range of 6.9 to pH 7.5 while the firing rate of mutant neurons remains constant at about 0.5 Hz over the same pH range

• there are no changes in the averaged I-V relationships obtained during extracellular acidification to alkalization while wild-type neurons rectify weakly and reverse near the expected Ek

respiratory system

respiratory system phenotype ( J:130850 )

N • whole animal ventilatory response to carbon dioxide is completely retained in this mice

Genotype
MGI:3806597

cx2

• Allelic Composition: Kcnk3^tm1.1Daba/Kcnk3^tm1.1Daba; Kcnk9^tm1.1Daba/Kcnk9^tm1.1Daba
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

nervous system phenotype ( J:130850 )

N • no abnormalities were found in the pH sensitivity of neurons in the retrotrapezoid nucleus

abnormal action potential ( J:130850 )

• serotonergic neurons within the raphe nucleus lack pH dependent-changes in discharge

• wild-type firing rates decrease from 1.2 Hz to 0.5 Hz over a pH range of 6.9 to pH 7.5 while the firing rate of mutant neurons remains constant at about 0.5 Hz over the same pH range

• there are no changes in the averaged I-V relationships obtained during extracellular acidification to alkalization while wild-type neurons rectify weakly and reverse near the expected Ek

respiratory system

respiratory system phenotype ( J:130850 )

N • whole animal ventilatory response to carbon dioxide is completely retained in this mice

Genotype
MGI:3796531

cx3

• Allelic Composition: Kcnk3^tm1.1Daba/Kcnk3^tm1.1Daba; Kcnk9^tm1.1Daba/Kcnk9^tm1.1Daba
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

homeostasis/metabolism

increased circulating aldosterone level ( J:131927 )

• males display primary hyperaldosteronism

• mutants fail to suppress aldosterone production in response to dietary sodium loading

• candesartan, an AT1R receptor blocker, does not normalize aldosterone production to control levels in mutants

hypokalemia ( J:131927 )

• mutants are mildly hypokalemic across all diets, with plasma potassium on the nonsalt diet reduced by about 25%

decreased circulating renin level ( J:131927 )

endocrine/exocrine glands

abnormal adrenal gland physiology ( J:131927 )

• adrenal zona glomerulosa cells display altered electrophysiological properties; the pH- and anesthetic-sensitive background currents are absent

• membrane potential is significantly more depolarized in mutant adrenal zona glomerulosa cells than in controls

• however, cellular morphology and zonation within the adrenal gland are normal in males

cardiovascular system

decreased heart rate ( J:131927 )

hypertension ( J:131927 )

nervous system

abnormal channel response ( J:131927 )

• adrenal zona glomerulosa cells display altered electrophysiological properties; the pH- and anesthetic-sensitive background currents are absent

• membrane potential is significantly more depolarized in mutant adrenal zona glomerulosa cells than in controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary hyperaldosteronism		DOID:446	OMIM:605635 OMIM:613677	J:131927