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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mef2dtm3Eno
targeted mutation 3, Eric Olson
MGI:3774341
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ighg1tm1(cre)Cgn/0
Mef2dtm3Eno/Mef2dtm3Eno 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:6401161
cn2
 		Mef2dtm3Eno/Mef2dtm3Eno
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * SJL MGI:3777090
cn3
 		Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2ctm2Eno/Mef2ctm2Eno
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:5560657
cn4
 		Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:5560659


Genotype
MGI:6401161
cn1
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2dtm3Eno/Mef2dtm3Eno
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2dtm3Eno mutation (0 available); any Mef2d mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:265465 )
N
• normal spleen germinal center (GC) B cell numbers 14 days after immunization with sheep red blood cells (SRBCs)




Genotype
MGI:3777090
cn2
Allelic
Composition		 Mef2dtm3Eno/Mef2dtm3Eno
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2dtm3Eno mutation (0 available); any Mef2d mutation (66 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:130825 )
• after 21 days of thoracic aortic constriction (TAC), mutant hearts display only a 27.7% increase in heart weight/tibia length, compared to 59% in wild-type hearts
• mutant hearts undergo less cardiac remodeling than wild-type in response to TAC
• mutants do not display fibrosis as result of pressure overload hypertrophy while extensive fibrosis is observed in wild-type
abnormal myocardial fiber morphology ( J:130825 )
• after pressure overload, mutant cardiomyocytes exhibit a considerably smaller increase in cross-sectional area composed to wild-type cardiomyocytes
abnormal heart size ( J:130825 )
• 21 days after TAC, mutant hearts show a smaller increase in heart weight/tibia length ratio versus wild-type
• after TAC, LV end-systolic diameter of mutant hearts is only marginally increased compared to wild-type hearts after TAC
decreased cardiac muscle contractility ( J:130825 )
• mutant hearts display a high level of resistance to reduction in heart muscle contractility after 21 days of TAC, whereas wild-type hearts show pronounced reduction in contractility

muscle
abnormal myocardial fiber morphology ( J:130825 )
• after pressure overload, mutant cardiomyocytes exhibit a considerably smaller increase in cross-sectional area composed to wild-type cardiomyocytes
decreased cardiac muscle contractility ( J:130825 )
• mutant hearts display a high level of resistance to reduction in heart muscle contractility after 21 days of TAC, whereas wild-type hearts show pronounced reduction in contractility




Genotype
MGI:5560657
cn3
Allelic
Composition		 Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2ctm2Eno/Mef2ctm2Eno
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Mef2ctm2Eno mutation (0 available); any Mef2c mutation (34 available)
Mef2dtm3Eno mutation (0 available); any Mef2d mutation (66 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:207812 )
• partial lethality by 5 weeks

nervous system
nervous system phenotype ( J:207812 )
N
• mice exhibit normal numbers of spines per length of dendrite in pyramidal neurons
abnormal long-term potentiation ( J:207812 )
• mice exhibit decreased input-output curve compared with wild-type mice
• however, long term potentiation is normal

growth/size/body
decreased body weight ( J:207812 )

cellular




Genotype
MGI:5560659
cn4
Allelic
Composition		 Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Mef2dtm3Eno mutation (0 available); any Mef2d mutation (66 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:207812 )
N
• mice exhibit normal learning and memory in context- and cue-dependent fear conditioning tests, normal anxiety-related behaviors and pain sensitivity
impaired coordination ( J:207812 )
• on a rotarod

nervous system
nervous system phenotype ( J:207812 )
N
• mice exhibit normal synapse number and basal synaptic transmission




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory