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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clnktm1Rygo
targeted mutation 1, Ryo Goitsuka
MGI:3774508
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clnktm1Rygo/Clnktm1Rygo B6.129P2-Clnktm1Rygo MGI:3777283
hm2
 		Clnktm1Rygo/Clnktm1Rygo involves: 129P2/OlaHsd * BALB/c MGI:3777291
cx3
 		Clnktm1Rygo/Clnktm1Rygo
Lcp2tm1Geha/Lcp2tm1Geha 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c MGI:3777289


Genotype
MGI:3777283
hm1
Allelic
Composition		 Clnktm1Rygo/Clnktm1Rygo
Genetic
Background		 B6.129P2-Clnktm1Rygo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clnktm1Rygo mutation (2 available); any Clnk mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131738 )
N
• natural killer and natural killer T cell development are normal
increased natural killer cell mediated cytotoxicity ( J:131738 )
• in vitro, natural killer (NK) cells are more efficient at killing YAC-1 cells and produce more IFN-gamma when stimulated with anti-Nk1.1 or Ly49D compared to wild-type NK cells
abnormal NK T cell physiology ( J:131738 )
• stimulated natural killer (NK) T cell produce less IFN-gamma and IL-4 (following CD3 cross-linking or exposure to alpha-GalCer) than stimulated wild-type NK T cells
abnormal interferon-gamma secretion ( J:131738 )
• when stimulated in vitro with anti-Nk1.1 or Ly49D, natural killer (NK) cells produce more IFN-gamma positive cells than when wild-type NK cells are used
• stimulated natural killer (NK) T cell produce less IFN-gamma than stimulated wild-type NK T cells
decreased interleukin-4 secretion ( J:131738 )
• stimulated natural killer (NK) T cell produce less IL-4 than stimulated wild-type NK T cells

hematopoietic system
increased natural killer cell mediated cytotoxicity ( J:131738 )
• in vitro, natural killer (NK) cells are more efficient at killing YAC-1 cells and produce more IFN-gamma when stimulated with anti-Nk1.1 or Ly49D compared to wild-type NK cells
abnormal NK T cell physiology ( J:131738 )
• stimulated natural killer (NK) T cell produce less IFN-gamma and IL-4 (following CD3 cross-linking or exposure to alpha-GalCer) than stimulated wild-type NK T cells




Genotype
MGI:3777291
hm2
Allelic
Composition		 Clnktm1Rygo/Clnktm1Rygo
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clnktm1Rygo mutation (2 available); any Clnk mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131621 )
N
• natural killer and natural killer T cell development are normal
increased natural killer cell mediated cytotoxicity ( J:131621 )
• natural killer (NK) cells are more efficient at killing EL-4 lymphoma target and BaF/3-Rae1gamma cells than wild-type NK cells
increased interferon-gamma secretion ( J:131621 )
• IFN-gamma production is increased following co-culture with YAC-1 cells

hematopoietic system
increased natural killer cell mediated cytotoxicity ( J:131621 )
• natural killer (NK) cells are more efficient at killing EL-4 lymphoma target and BaF/3-Rae1gamma cells than wild-type NK cells




Genotype
MGI:3777289
cx3
Allelic
Composition		 Clnktm1Rygo/Clnktm1Rygo
Lcp2tm1Geha/Lcp2tm1Geha
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clnktm1Rygo mutation (2 available); any Clnk mutation (31 available)
Lcp2tm1Geha mutation (0 available); any Lcp2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:131621 )
• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells
decreased interferon-gamma secretion ( J:131621 )
• alpha-GalCer-stimulated IFN-gamma secretion form spleen natural killer T cells is absent despite the presence of the cells
• however, natural killer cells co-cultured with YAC-1 cells produce normal levels of IFN-gamma

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:131621 )
• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory