All Phenotypes Cerk<tm1Fbor> MGI Mouse

increased susceptibility to induced morbidity/mortality ( J:131522 )

• following infection leading to pneumonia mice exhibit a drop of day 4 survival to 25% compared to 100% in wild-type mice

abnormal ceramide level ( J:137892 )

• reduction in C16-C1P ceramides in the retina but increased ceramide levels compared with wild-type mice

immune system phenotype ( J:131522 )

N	• mice exhibit normal macrophages and mast cells

decreased granulocyte number ( J:131522 )

• the number of granulocytes in the spleen and blood is decreased by at least 50% of wild-type

• however, granulocyte numbers within bone marrow are normal

decreased neutrophil cell number ( J:131522 )

• mice exhibit neutroprenia due to increased priming for apoptosis

• however, migration and adherence of neutrophils is normal

increased leukocyte cell number ( J:131522 )

• the number of leukocytes other than neutrophils is increased in the bone marrow and spleen compared to in wild-type mice

• however, organomegaly is not observed

increased susceptibility to bacterial infection ( J:131522 )

• 3 days after infection mice develop a worsened course of pneumonia compared to wild-type mice resulting in increased weight loss, larger lung bacterial counts and decreased survival rates

decreased body weight ( J:131522 )

• adult mice exhibit a 10% to 15% reduction in body weight