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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cfptm1Cmst
targeted mutation 1, Cordula M Stover
MGI:3774548
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cfptm1Cmst/Cfptm1Cmst B6.129P2-Cfptm1Cmst MGI:3775407
ot2
 		Cfptm1Cmst/Y involves: 129P2/OlaHsd * C57BL/6 MGI:5427500


Genotype
MGI:3775407
hm1
Allelic
Composition		 Cfptm1Cmst/Cfptm1Cmst
Genetic
Background		 B6.129P2-Cfptm1Cmst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfptm1Cmst mutation (0 available); any Cfp mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:131526 )
• only 6 of 16 mice survived 7 days after cecal ligation and puncture compared to 14 of 16 wild-type mice as a result of septic peritonitis

immune system
sepsis ( J:131526 )
• only 6 of 16 mice survived 7 days after cecal ligation and puncture compared to 14 of 16 wild-type mice as a result of septic peritonitis




Genotype
MGI:5427500
ot2
Allelic
Composition		 Cfptm1Cmst/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfptm1Cmst mutation (0 available); any Cfp mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to injury ( J:182612 )
• males are protected from developing elastase-induced abdominal aortic aneurysm
• adoptive transfer of wild-type neutrophils into mutant males induces small abdominal aortic aneurysm after elastase perfusion, while transfer of wild-type serum restores abdominal aortic aneurysm to wild-type levels in mutants

cardiovascular system
abnormal cardiovascular system physiology ( J:182612 )
• males are protected from developing elastase-induced abdominal aortic aneurysm




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory