All Phenotypes Notch1<tm2Pst> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch1^tm2Pst/Notch1^tm2Pst	B6.Cg-Notch1^tm2Pst	MGI:3775286
ht2	Notch1^tm2Pst/Notch1^tm2.1Pst	B6.Cg-Notch1^tm2.1Pst	MGI:3775287
ht3	Notch1^tm2Pst/Notch1^tm2.1Pst	involves: 129/Sv * C57BL/6 * SJL	MGI:3775288
cx4	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Notch1^tm2Pst/Notch1⁺	involves: 129/Sv * C57BL/6J * DBA/2 * SJL	MGI:7640233

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:131563 )

• thymocytes, more specifically double positive T cells, exhibit increased levels of apoptosis compared to wild-type thymocytes

abnormal T cell differentiation ( J:131563 )

• all of the more mature T cell subsets are decreased compared to in wild-type mice

• mice exhibit fewer CD45.2+ double positive T cells following donor transplant than wild-type mice

• the transition from double positive to single positive is enhanced

• however, emigration of T cells to the spleen is normal

decreased double-negative T cell number ( J:131563 )

• the number of CD44-CD25- DN4 cells is decreased 40% compared to in wild-type mice

• however, the number of DN3 T cells is slightly increased

decreased T cell number ( J:131563 )

• all of the more mature T cell subsets are decreased compared to in wild-type mice

decreased thymocyte number ( J:131563 )

• the thymus contains 50% fewer thymocytes than in wild-type mice

• however, emigration of T cells to the spleen is normal

growth/size/body

postnatal growth retardation ( J:131563 )

• mice grow slower than wild-type mice after weaning

hematopoietic system

increased T cell apoptosis ( J:131563 )

• thymocytes, more specifically double positive T cells, exhibit increased levels of apoptosis compared to wild-type thymocytes

abnormal T cell differentiation ( J:131563 )

• all of the more mature T cell subsets are decreased compared to in wild-type mice

• mice exhibit fewer CD45.2+ double positive T cells following donor transplant than wild-type mice

• the transition from double positive to single positive is enhanced

• however, emigration of T cells to the spleen is normal

decreased T cell number ( J:131563 )

• all of the more mature T cell subsets are decreased compared to in wild-type mice

decreased thymocyte number ( J:131563 )

• the thymus contains 50% fewer thymocytes than in wild-type mice

• however, emigration of T cells to the spleen is normal

decreased double-negative T cell number ( J:131563 )

• the number of CD44-CD25- DN4 cells is decreased 40% compared to in wild-type mice

• however, the number of DN3 T cells is slightly increased

cellular

increased T cell apoptosis ( J:131563 )

• thymocytes, more specifically double positive T cells, exhibit increased levels of apoptosis compared to wild-type thymocytes

endocrine/exocrine glands

decreased thymocyte number ( J:131563 )

• the thymus contains 50% fewer thymocytes than in wild-type mice

• however, emigration of T cells to the spleen is normal

Allelic Composition	Notch1^tm2Pst/Notch1^tm2.1Pst
Genetic Background	B6.Cg-Notch1^tm2.1Pst

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm2.1Pst mutation (0 available); any Notch1 mutation (117 available)
Notch1^tm2Pst mutation (0 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131563 )

• mice die at E10

embryo

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 13 to 17 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes

growth/size/body

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 13 to 17 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes

Allelic Composition	Notch1^tm2Pst/Notch1^tm2.1Pst
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131563 )

• mice die around E12

embryo

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes and 13 to 17 in Notch1^tm2.1Pst homozygotes

decreased embryo size ( J:131563 )

• at E10.5

abnormal embryonic neuroepithelium morphology ( J:131563 )

• at E10.5

cardiovascular system

abnormal vasculogenesis ( J:131563 )

• at E10.5 mice are anemic due to defects in vasculogenesis

abnormal heart development ( J:131563 )

• at E10.5, mice exhibit an underdeveloped heart loop

nervous system

abnormal embryonic neuroepithelium morphology ( J:131563 )

• at E10.5

hematopoietic system

anemia ( J:131563 )

• at E10.5 mice are anemic due to defects in vasculogenesis

growth/size/body

embryonic growth retardation ( J:131563 )

• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1^tm2Pst homozygotes and 13 to 17 in Notch1^tm2.1Pst homozygotes

decreased embryo size ( J:131563 )

• at E10.5

Allelic Composition	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Notch1^tm2Pst/Notch1⁺
Genetic Background	involves: 129/Sv * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eogt^tm1.2Okaj mutation (0 available); any Eogt mutation (44 available)
Notch1^tm2Pst mutation (0 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single mutant, with even greater vessel branching and number of filopodia

vision/eye

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single mutant, with even greater vessel branching and number of filopodia

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