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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor
targeted mutation 1, David M Ornitz
MGI:3774555
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+ 		involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:3775280
cn2
 		Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor
Myl2tm1(cre)Krc/Myl2+ 		involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:3775278
cn3
 		Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+ 		involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:3775279


Genotype
MGI:3775280
cn1
Allelic
Composition		 Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Upir mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
heart hypoplasia ( J:131577 )
• mice exhibit smaller hearts than mice homozygous for null alleles of Fgfr1 and Fgfr2 due to decreased myocardial proliferation
• however, coronary development is normal
thin ventricular wall ( J:131577 )
• mice exhibit thinner ventricular walls than mice homozygous for null alleles of Fgfr1 and Fgfr2




Genotype
MGI:3775278
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor
Myl2tm1(cre)Krc/Myl2+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
heart hypoplasia ( J:131577 )
• mice exhibit small hearts due to decreased myocardial proliferation
• however, coronary development is normal
thin ventricular wall ( J:131577 )
• the ventricular wall thickness is 54+/-6% of wild-type mice




Genotype
MGI:3775279
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
heart hypoplasia ( J:131577 )
• mice exhibit small hearts due to decreased myocardial proliferation
• however, coronary development is normal
thin ventricular wall ( J:131577 )
• the ventricular wall thickness is 67+/-8% of wild-type but not as thin as in homozygotes (54+/-6%)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory