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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atf2tm3Nicj
targeted mutation 3, Nic Jones
MGI:3774771
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atf2tm3Nicj/Atf2tm3Nicj involves: C57BL/6 * FVB/N MGI:3774839
cn2
 		Atf2tm3Nicj/Atf2tm3Nicj
Tg(KRT14-cre)1Efu/? 		involves: C57BL/6 * FVB/N MGI:3774840


Genotype
MGI:3774839
hm1
Allelic
Composition		 Atf2tm3Nicj/Atf2tm3Nicj
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm3Nicj mutation (0 available); any Atf2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:131564 )
• mice were born at the expected Mendelian frequencies and presented no obvious abnormalities




Genotype
MGI:3774840
cn2
Allelic
Composition		 Atf2tm3Nicj/Atf2tm3Nicj
Tg(KRT14-cre)1Efu/?
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm3Nicj mutation (0 available); any Atf2 mutation (89 available)
Tg(KRT14-cre)1Efu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin papilloma incidence ( J:131564 )
• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls

integument
epidermal hyperplasia ( J:131564 )
• the percentage of proliferating epithelial cells after TPA administration is twice that of littermate controls
• reduced levels of active caspase 3 were observed in the skin of mice treated with carcinogens suggesting apoptosis levels might be lower
thick epidermis ( J:131564 )
• mice develop a significantly thickened hyperdermis after three topical applications of TPA
• thickness is twice that of wild-type mice after TPA application
increased skin papilloma incidence ( J:131564 )
• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory