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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTA1-SMN)63Ahmb
transgene insertion 63, Arthur H M Burghes
MGI:3774939
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb 		involves: 129P2/OlaHsd * FVB/N MGI:3775247
cx2
 		Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb 		involves: 129P2/OlaHsd * FVB/N MGI:3775248
tg3
 		Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb involves: FVB/N MGI:3775199
tg4
 		Tg(ACTA1-SMN)63Ahmb/0 involves: FVB/N MGI:3775200


Genotype
MGI:3775247
cx1
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm7Tg(SMN2)89Ahmb mutation (34 available); any Grm7 mutation (125 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(ACTA1-SMN)63Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:131663 )
• double mutants survive an average of 6.6 days, with some living past 15 days, representing a slight but significant increase compared to Smn1tm1Msd homozygotes




Genotype
MGI:3775248
cx2
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm7Tg(SMN2)89Ahmb mutation (34 available); any Grm7 mutation (125 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(ACTA1-SMN)63Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:131663 )
• double mutants survive an average of 160 days, with some living up to a year

muscle
decreased skeletal muscle fiber size ( J:131663 )
• muscle fiber distribution is different from normal muscle; mice have a greater number of smaller diameter fibers relative to controls

limbs/digits/tail
tail necrosis ( J:131663 )
• tail becomes necrotic by 21 days of age, resulting in tail being very short




Genotype
MGI:3775199
tg3
Allelic
Composition		 Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTA1-SMN)63Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:131663 )
• expression of the transgene does not adversely affect the phenotype relative to wild-type




Genotype
MGI:3775200
tg4
Allelic
Composition		 Tg(ACTA1-SMN)63Ahmb/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTA1-SMN)63Ahmb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:131663 )
• expression of the transgene does not adversely affect the phenotype relative to wild-type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory