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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTA1-SMN)69Ahmb
transgene insertion 69, Arthur H M Burghes
MGI:3774944
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N MGI:3775240
tg2
Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb involves: FVB/N MGI:3775201
tg3
Tg(ACTA1-SMN)69Ahmb/0 involves: FVB/N MGI:3775198


Genotype
MGI:3775240
cx1
Allelic
Composition
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm7Tg(SMN2)89Ahmb mutation (34 available); any Grm7 mutation (125 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(ACTA1-SMN)69Ahmb mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice survive an average of 3.5 days, not significantly different from mean lifespan of 4.6 days of Smn1tm1Msd homozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Werdnig-Hoffmann disease DOID:13137 OMIM:253300
J:131663




Genotype
MGI:3775201
tg2
Allelic
Composition
Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTA1-SMN)69Ahmb mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• expression of the transgene does not adversely affect the phenotype relative to wild-type




Genotype
MGI:3775198
tg3
Allelic
Composition
Tg(ACTA1-SMN)69Ahmb/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTA1-SMN)69Ahmb mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• expression of the transgene does not adversely affect the phenotype relative to wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory