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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Espl1tm2Pzg
targeted mutation 2, Pumin Zhang
MGI:3775062
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Espl1tm2Pzg/Espl1tm2Pzg involves: 129S7/SvEvBrd MGI:3776847
cn2
 		Espl1tm2Pzg/Espl1+
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd MGI:3776851


Genotype
MGI:3776847
hm1
Allelic
Composition		 Espl1tm2Pzg/Espl1tm2Pzg
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm2Pzg mutation (0 available); any Espl1 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3776851
cn2
Allelic
Composition		 Espl1tm2Pzg/Espl1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm2Pzg mutation (0 available); any Espl1 mutation (95 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogonia morphology ( J:131838 )
• lack spermatogonia
absent primordial germ cells ( J:131838 )
• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
decreased primordial germ cell proliferation ( J:131838 )
• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc
small testis ( J:131838 )
• significantly smaller testes at 6 wks of age
abnormal spermatogenesis ( J:131838 )
• no sign of spermatogenesis detected at 2 wks of age, due to spermatogonia cell depletion
abnormal spermatid morphology ( J:131838 )
• absence of spermatids in seminiferous tubules
abnormal spermatocyte morphology ( J:131838 )
• absence of spermatocytes in seminiferous tubules
infertility ( J:131838 )
• both sexes are sterile

cellular
abnormal spermatid morphology ( J:131838 )
• absence of spermatids in seminiferous tubules
abnormal spermatocyte morphology ( J:131838 )
• absence of spermatocytes in seminiferous tubules
abnormal spermatogonia morphology ( J:131838 )
• lack spermatogonia
absent primordial germ cells ( J:131838 )
• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
abnormal centrosome morphology ( J:131838 )
• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
aneuploidy ( J:131838 )
• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
abnormal mitosis ( J:131838 )
• abnormal metaphase configuration of mutant PGCs at 13.5 dpc
• precocious sister chromatid separation and arrest of PGCs in mitosis due to spindle checkpoint activation
increased mitotic index ( J:131838 )
• significantly higher mitotic indices in mutant PGCs than controls at 12.5, 13.5, and 14.5 dpc
decreased primordial germ cell proliferation ( J:131838 )
• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc

embryo
abnormal gonadal ridge morphology ( J:131838 )
• higher levels of activated caspase-3, p53, and Bax in extracts of 13.5 dpc mutant genital ridges than in controls, suggesting p53-related apoptosis of mutant PGCs

endocrine/exocrine glands
small testis ( J:131838 )
• significantly smaller testes at 6 wks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory