Allele Symbol Allele Name Allele ID |
Espl1tm2Pzg targeted mutation 2, Pumin Zhang MGI:3775062 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• lack spermatogonia
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• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
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• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc
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• significantly smaller testes at 6 wks of age
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• no sign of spermatogenesis detected at 2 wks of age, due to spermatogonia cell depletion
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• absence of spermatids in seminiferous tubules
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• absence of spermatocytes in seminiferous tubules
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• both sexes are sterile
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• absence of spermatids in seminiferous tubules
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• absence of spermatocytes in seminiferous tubules
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• lack spermatogonia
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• lack of primordial germ cells by E14.5 (early germ cell marker Mvh absent)
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• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
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• abnormal centrosome number (>2) in some mutant PGCs at 13.5 dpc
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• abnormal metaphase configuration of mutant PGCs at 13.5 dpc
• precocious sister chromatid separation and arrest of PGCs in mitosis due to spindle checkpoint activation
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• significantly higher mitotic indices in mutant PGCs than controls at 12.5, 13.5, and 14.5 dpc
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• primordial germ cells migrate to genital ridge but fail to proliferate normally between 11.5 and 14.5 dpc
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• higher levels of activated caspase-3, p53, and Bax in extracts of 13.5 dpc mutant genital ridges than in controls, suggesting p53-related apoptosis of mutant PGCs
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• significantly smaller testes at 6 wks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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