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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptrh2tm1Eruo
targeted mutation 1, Erkki Ruoslahti
MGI:3775073
Summary 2 genotypes


Genotype
MGI:3776794
hm1
Allelic
Composition		 Ptrh2tm1Eruo/Ptrh2tm1Eruo
Genetic
Background		 C57BL/6-Ptrh2tm1Eruo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptrh2tm1Eruo mutation (1 available); any Ptrh2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:131853 )
• mice are viable and fertile




Genotype
MGI:5634971
cn2
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic
Background		 B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Ptrh2tm1.1Eruo mutation (0 available); any Ptrh2 mutation (36 available)
Ptrh2tm1Eruo mutation (1 available); any Ptrh2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
cachexia ( J:220518 )
postnatal growth retardation ( J:220518 )
• progressive age related relative decrease in length and weight

nervous system
decreased brain weight ( J:220518 )
• slightly but significantly decreased at P7
abnormal cerebral cortex morphology ( J:220518 )
• neuron soma size is reduced in the cerebral cortex
cerebellum atrophy ( J:220518 )
• cerebellar atrophy at P7

endocrine/exocrine glands
abnormal pancreatic acinar cell morphology ( J:220518 )
• reduced cross section areas of the pancreatic acini at P7
exocrine pancreatic insufficiency ( J:220518 )
• at P7 as indicated by reduced pancreas elastase levels in the stool and reduced cross section areas of the pancreatic acini

behavior/neurological
ataxia ( J:220518 )
• severe at P7

muscle
abnormal muscle fiber morphology ( J:220518 )
• decreased myocyte soma size

liver/biliary system
abnormal hepatocyte morphology ( J:220518 )
• decreased soma size

digestive/alimentary system
abnormal pancreatic acinar cell morphology ( J:220518 )
• reduced cross section areas of the pancreatic acini at P7
exocrine pancreatic insufficiency ( J:220518 )
• at P7 as indicated by reduced pancreas elastase levels in the stool and reduced cross section areas of the pancreatic acini




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory