mortality/aging
• homozygotes develop normally until E11 but are dead by E12
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cardiovascular system
• isolated cardiomyocytes beat more slowly
• slower activation of currents in cardiomyocytes
• faster deactivation of currents in cardiomyocytes
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• embryos display a reduced heart rate between E9.5 and E11.5
• superfusion of either isoproterenol or NKH477 fails to bring about an increase in heart rate
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muscle
• isolated cardiomyocytes beat more slowly
• slower activation of currents in cardiomyocytes
• faster deactivation of currents in cardiomyocytes
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