Phenotypes associated with this allele

• Allele Symbol: Phb2^tm1Tlan
• Allele Name: targeted mutation 1, Thomas Langer
• Allele ID: MGI:3775179
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Phb2^tm1Tlan/Phb2^tm1Tlan	involves: C57BL/6 * SJL	MGI:3776668

Genotype
MGI:3776668

cn1

• Allelic Composition: Phb2^tm1Tlan/Phb2^tm1Tlan
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial morphology ( J:131699 )

• after Cre-transduction, over 90% of MEFS show fragmented mitochondria many of which have defective cristae

increased sensitivity to induced cell death ( J:131699 )

• after Cre-transduction, MEFS show increased sensitivity to intrinsic and extrinsic apoptotic stimuli but no increase in spontaneous apoptosis

decreased fibroblast proliferation ( J:131699 )

• impaired proliferation after transduction of MEFs with purified Cre-recombinase