Phenotypes associated with this allele

• Allele Symbol: Rela^tm1Asba
• Allele Name: targeted mutation 1, Albert S Baldwin
• Allele ID: MGI:3775205
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rela^tm1Asba/Rela^tm1Asba Tg(Vil1-cre)997Gum/0	involves: 129 * C57BL/6J * SJL	MGI:3799251

Genotype
MGI:3799251

cn1

• Allelic Composition: Rela^tm1Asba/Rela^tm1Asba; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:131977 )

• following removal of DSS treatment, mice exhibit increased mortality compared to similarly treated wild-type mice

decreased survivor rate ( J:131977 )

• 10% to 15% of mice develop intestinal problems and die prior to day 25

premature death ( J:131977 )

• mice with abdominal irregularities die prior to day 25

digestive/alimentary system

diarrhea ( J:131977 )

• at 2 to 3 days after birth, 10% to 15% of mice exhibit diarrhea and abdominal discoloration unlike wild-type mice

abnormal intestinal epithelium morphology ( J:131977 )

• cell proliferation and apoptosis of the epithelial layer in the colon is increased compared to in wild-type mice

megacolon ( J:131977 )

• distended with air or dark material in 10% to 15% of mice

abnormal small intestine morphology ( J:131977 )

• 10% to 15% of mice exhibit a thin-walled, pale small intestine

abnormal small intestine crypts of Lieberkuhn morphology ( J:131977 )

• severely affected animals display a nearly complete loss of crypt-villus structure in the ileum

abnormal small intestinal villus morphology ( J:131977 )

• severely affected animals display a nearly complete loss of crypt-villus structure in the ileum

impaired intestine regeneration ( J:131977 )

• despite removal of DSS mice continue to exhibit increased intestinal epithelial apoptosis and fail to recover unlike wild-type mice

increased susceptibility to induced colitis ( J:131977 )

• mice are more susceptible to colitis induced by long term DSS treatment than wild-type mice

• unlike wild-type mice, after 5 to 7 days of treatment with DSS mice exhibit rectal bleeding, more severe weight loss, increased mucosal damage, colon epithelial cell proliferation and apoptosis, increased PGE2, IL-6 and MCP-1 levels, and increased immune response

• following removal of DSS treatment, mice exhibit increased mortality compared to similarly treated wild-type mice

• despite removal of DSS mice continue to exhibit increased intestinal epithelial apoptosis

growth/size/body

slow postnatal weight gain ( J:131977 )

• mice with abdominal irregularities exhibit decreased postnatal weight gain compared to wild-type mice

immune system

increased susceptibility to induced colitis ( J:131977 )

• mice are more susceptible to colitis induced by long term DSS treatment than wild-type mice

• unlike wild-type mice, after 5 to 7 days of treatment with DSS mice exhibit rectal bleeding, more severe weight loss, increased mucosal damage, colon epithelial cell proliferation and apoptosis, increased PGE2, IL-6 and MCP-1 levels, and increased immune response

• following removal of DSS treatment, mice exhibit increased mortality compared to similarly treated wild-type mice

• despite removal of DSS mice continue to exhibit increased intestinal epithelial apoptosis

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:131977 )

• severely affected animals display a nearly complete loss of crypt-villus structure in the ileum

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:131977 )

• following removal of DSS treatment, mice exhibit increased mortality compared to similarly treated wild-type mice