Phenotypes associated with this allele

• Allele Symbol: Apln^tm1Ntak
• Allele Name: targeted mutation 1, Nobuyuki Takakura
• Allele ID: MGI:3775290
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apln^tm1Ntak/Apln^tm1Ntak	involves: 129X1/SvJ * C57BL/6J	MGI:3775305
cx2	Apln^tm1Ntak/Apln^tm1Ntak Tg(KRT14-Angpt1)1Gdy/0	involves: 129X1/SvJ * C57BL/6J	MGI:3775306

Genotype
MGI:3775305

hm1

• Allelic Composition: Apln^tm1Ntak/Apln^tm1Ntak
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased capillary density ( J:131824 )

♀ • decrease in tracheal capillary density

vascular stenosis ( J:131824 )

♀ • intersomitic, tracheal, dermal, and cardiac blood vessels are narrower

♀ • however, the sizes of large vessels (aorta, vena cava, branchiocephalic artery, subclavian artery, and common iliac artery) are unaffected

embryo

embryo phenotype ( J:131824 )

♀N • despite abnormalities seen in the vitelline vasculature of Xenopus mutants, remodeling of the vitelline vasculature is unaffected in homozygous mice

growth/size/body

weight loss ( J:131824 )

♀ • seen in a small number of mice

vision/eye

anophthalmia ( J:131824 )

♀ • seen in a small number of mice

Genotype
MGI:3775306

cx2

• Allelic Composition: Apln^tm1Ntak/Apln^tm1Ntak; Tg(KRT14-Angpt1)1Gdy/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

cardiovascular system

abnormal capillary morphology ( J:131824 )

♀ • increased size of capillaries in the dermis

♀ • significant decrease in the number of very large (greater than 10^4 micrometers squared) but only a slight, non-significant decrease in the number of large (greater than 5 x 10^3 micrometers squared) compared to transgenic mice that express Apln