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Allele Symbol Allele Name Allele ID |
Apctm2Cip targeted mutation 2, Christine Perret MGI:3775293 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced visible and total lesions in the small intestine
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• reduced visible and total lesions in the small intestine
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| N |
• no increase in apoptosis is observed in non tumor tissue
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hunching appears in some animals at 90 days of age
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• increased size and number of small intestine adenomas
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• increased size and number of small intestine adenomas
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tumors in small intestine are almost absent at 120 days of age
• fewer and smaller tumors at 90 days of age as well
• decrease in numbers of tumors between 90 and 120 days
• no increase in tumor size between 90 and 120 days
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• also reduced at 120 days
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• adenomas are one tenth the size of those found in controls at 120 days of age
• increased cell proliferation in adenomas at 90 days
• increased apoptosis in smaller adenomas but not larger ones at 90 days
• apoptosis is also increased in non tumor tissue
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• increased apoptosis in smaller adenomas but not larger ones at 90 days
• apoptosis is also increased in non tumor tissue
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• tumors in small intestine are almost absent at 120 days of age
• fewer and smaller tumors at 90 days of age as well
• decrease in numbers of tumors between 90 and 120 days
• no increase in tumor size between 90 and 120 days
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• also reduced at 120 days
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• adenomas are one tenth the size of those found in controls at 120 days of age
• increased cell proliferation in adenomas at 90 days
• increased apoptosis in smaller adenomas but not larger ones at 90 days
• apoptosis is also increased in non tumor tissue
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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