Phenotypes associated with this allele

• Allele Symbol: Tcrb^tm1(Tcrb)Fwa
• Allele Name: targeted mutation 1, Frederick W Alt
• Allele ID: MGI:3775389
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcrb^tm1(Tcrb)Fwa/Tcrb^tm1(Tcrb)Fwa	involves: 129	MGI:3775397

Genotype
MGI:3775397

hm1

• Allelic Composition: Tcrb^tm1(Tcrb)Fwa/Tcrb^tm1(Tcrb)Fwa
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell receptor beta chain V(D)J recombination ( J:131995 )

• thymocytes and splenocytes completely lack cell surface expression of Vbeta14 segment

• recombination of the knocked in gene segments occurs in T but not B- cells

• rearrangement occurred 80% to 90% of the time as opposed to 5% of the time for the endogenous gene segment

immune system

abnormal T cell receptor beta chain V(D)J recombination ( J:131995 )

• thymocytes and splenocytes completely lack cell surface expression of Vbeta14 segment

• recombination of the knocked in gene segments occurs in T but not B- cells

• rearrangement occurred 80% to 90% of the time as opposed to 5% of the time for the endogenous gene segment