cardiovascular system
N |
• aortic valves appear normal at 16 weeks of age, showing no signs of disease
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Allele Symbol Allele Name Allele ID |
Tg(Col6a1-cre)1Gkl transgene insertion 1, George Kollias MGI:3775430 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• aortic valves appear normal at 16 weeks of age, showing no signs of disease
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice show amelioration of the aortic valve stenosis seen in single Tnftm2Gkl heterozygotes, including a decrease of the leaflets surface area and reduction of fibrosis
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• mice show reduced clinical features of arthritis compared to single Tnftm2Gkl heterozygotes, with a reduction of pannus formation and cartilage/bone destruction
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• valvular interstitial cells fail to become activated
• however, cultured valvular interstitial cells appear similar to wild-type cells and exhibit normal proliferation
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• synovial fibroblast and valvular interstitial cell adhesion to a fibronectin substrate is reduced by almost 50% compared to the levels in single Tnftm2Gkl heterozygotes but is somewhat higher than in wild-type cells
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• synovial fibroblasts fail to become activated
• however, cultured synovial fibroblasts appear similar to wild-type cells and exhibit normal proliferation
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• circulating TNF levels are elevated
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• synovial fibroblasts and valvular interstitial cells show only 40-45% closure of a wound in culture compared to 70-80% closure in single Tnftm2Gkl heterozygotes and about 20% in wild-type cells
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• circulating TNF levels are elevated
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• levels of secreted TNF-alpha in supernatants of cultured synovial fibroblasts and valvular interstitial cells are elevated
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• mice show reduced clinical features of arthritis compared to single Tnftm2Gkl heterozygotes, with a reduction of pannus formation and cartilage/bone destruction
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the ileum contains inflammatory pathology reminiscent of Crohn's disease
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers
• 100% of mice have disease by 8 weeks of age
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• the ileum contains inflammatory pathology reminiscent of Crohn's disease
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers
• 100% of mice have disease by 8 weeks of age
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• 100% of mice have arthritis by 8 weeks of age
• joints are infiltrated by mononuclear cells
• mice also develop spondyloarthritis in their sacroiliac joints
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• 100% of mice have arthritis by 8 weeks of age
• joints are infiltrated by mononuclear cells
• mice also develop spondyloarthritis in their sacroiliac joints
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are born at the expected ratios, are viable, and fertile and do not display any spontaneous phenotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• decreased in mice treated with AOM/DSS
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• increased in mice treated with AOM/DSS
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• high-grade dysplasia in mice treated with AOM/DSS
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• higher tumor burdens and tumor size in mice treated with AOM/DSS
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• higher tumor burdens and tumor size in mice treated with AOM/DSS
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• decreased in mice treated with AOM/DSS
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• increased in mice treated with AOM/DSS
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N |
• mice treated with AOM/DSS exhibit normal body weight loss, decreased colon length, inflammation and tissue damage
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• higher tumor burdens and tumor size in mice treated with AOM/DSS
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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