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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1atm2.1Vei
targeted mutation 2.1, Andre Veillette
MGI:3775432
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sh2d1atm2.1Vei/Sh2d1atm2.1Vei involves: C57BL/6 MGI:3775440


Genotype
MGI:3775440
hm1
Allelic
Composition		 Sh2d1atm2.1Vei/Sh2d1atm2.1Vei
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm2.1Vei mutation (0 available); any Sh2d1a mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:131618 )
• the number of NK T cells is decreased 90% compared to in wild-type mice
decreased IgE level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG1 level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG2a level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG2b level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG3 level ( J:131618 )
• following immunization with TNP-CGG
decreased IgM level ( J:131618 )
• following immunization with TNP-CGG

hematopoietic system
decreased NK T cell number ( J:131618 )
• the number of NK T cells is decreased 90% compared to in wild-type mice
decreased IgE level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG1 level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG2a level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG2b level ( J:131618 )
• following immunization with TNP-CGG
decreased IgG3 level ( J:131618 )
• following immunization with TNP-CGG
decreased IgM level ( J:131618 )
• following immunization with TNP-CGG




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory