Phenotypes associated with this allele

• Allele Symbol: Hfe^tm1Wsr
• Allele Name: targeted mutation 1, Wolfgang Stremmel
• Allele ID: MGI:3775647
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hfe^tm1Wsr/Hfe^tm1Wsr Lyz2^tm1(cre)Ifo/?	involves: 129P2/OlaHsd * C57BL/6	MGI:3775663
cn2	Hfe^tm1Wsr/Hfe^tm1Wsr Tg(Alb1-cre)7Gsc/?	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3775662
cn3	Hfe^tm1Wsr/Hfe^tm1Wsr Tg(Vil1-cre)997Gum/?	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3821583

Genotype
MGI:3775663

cn1

• Allelic Composition: Hfe^tm1Wsr/Hfe^tm1Wsr; Lyz2^tm1(cre)Ifo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:132134 )

N • iron homeostasis is normal in these mice

Genotype
MGI:3775662

cn2

• Allelic Composition: Hfe^tm1Wsr/Hfe^tm1Wsr; Tg(Alb1-cre)7Gsc/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

homeostasis/metabolism

decreased spleen iron level ( J:132134 )

• non-heme splenic iron levels are significantly reduced compared to littermate controls

increased circulating iron level ( J:132134 )

• plasma iron levels are significantly elevated compared to age and sex matched controls

• transferrin saturation is significantly elevated and the unsaturated iron binding capacity is significantly reduced

increased liver iron level ( J:132134 )

• iron accumulates in the parenchymal cells of the liver

• iron levels are 3- to 6- fold higher than littermate controls

hemochromatosis ( J:132134 )

• symptoms in mice are consistent with hemocromatosis

hematopoietic system

decreased spleen iron level ( J:132134 )

• non-heme splenic iron levels are significantly reduced compared to littermate controls

immune system

decreased spleen iron level ( J:132134 )

• non-heme splenic iron levels are significantly reduced compared to littermate controls

liver/biliary system

increased liver iron level ( J:132134 )

• iron accumulates in the parenchymal cells of the liver

• iron levels are 3- to 6- fold higher than littermate controls

Genotype
MGI:3821583

cn3

• Allelic Composition: Hfe^tm1Wsr/Hfe^tm1Wsr; Tg(Vil1-cre)997Gum/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:141745 )

• mice are viable, fertile and have no detectable defects in iron homeostasis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	hemochromatosis type 1	DOID:0111029	OMIM:235200	J:141745