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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ifnlr1tm1Palu
targeted mutation 1, Soren R Paludan
MGI:3775762
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ifnlr1tm1Palu/Ifnlr1tm1Palu B6.Cg-Ifnlr1tm1Palu MGI:3775763
hm2
Ifnlr1tm1Palu/Ifnlr1tm1Palu involves: BALB/c * C57BL/6 MGI:6403849


Genotype
MGI:3775763
hm1
Allelic
Composition
Ifnlr1tm1Palu/Ifnlr1tm1Palu
Genetic
Background
B6.Cg-Ifnlr1tm1Palu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnlr1tm1Palu mutation (0 available); any Ifnlr1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the murine model for genital herpes, in which local administration of TLR3 and TLR9 ligands induces a strong antiviral response, viral titers were significantly higher in mutant mice and developed signs of disease to a higher extent than did the wild-type
• mutant mice were otherwise indistinguishable from wild-type mice with respect to clearance of a panel of different viruses




Genotype
MGI:6403849
hm2
Allelic
Composition
Ifnlr1tm1Palu/Ifnlr1tm1Palu
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnlr1tm1Palu mutation (0 available); any Ifnlr1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice infected with the Urbani strain of severe acute respiratory syndrome coronavirus (SARS-CoV) or a recombinant isogenic mouse-adapted SARS-CoV (rMA15) that contains six virulence modifying mutations show no increase in susceptibility, pathogenesis, or histological outcomes to infection compared to wild-type controls





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory